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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Dec. 31, 2019 USD ($) shares | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) shares | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2019 USD ($) segment $ / shares shares | Dec. 31, 2018 USD ($) shares | Dec. 31, 2017 USD ($) shares | Jan. 01, 2019 USD ($) | Jan. 01, 2018 USD ($)
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues | $ 54,851 | $ 21,958 | $ 17,548 | $ 8,071 | $ 26,837 | $ 23,562 | $ 21,416 | $ 12,637 | $ 102,428 | $ 84,452 | $ 36,567 |  |
Net loss | 4,501 | $ (27,361) | $ (30,356) | $ (42,203) | $ (19,219) | $ (12,843) | $ (16,640) | $ (20,187) | (95,419) | $ (68,889) | $ (54,568) |  |
Letter of credit | $ 1,500 |  |  |  |  |  |  |  | $ 1,500 |  |  |  |
Stock options and RSUs outstanding (in shares) | shares | 10,750,550 |  |  |  | 9,048,793 |  |  |  | 10,750,550 | 9,048,793 | 8,367,628 |  |
Number of operating segments | segment |  |  |  |  |  |  |  |  | 1 |  |  |  |
Cumulative effect of new accounting principle in period of adoption |  |  |  |  |  |  |  |  |  |  |  | $ (897) | $ (1,117)
Accumulated Deficit |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  |  |  |  |  |  | $ (95,186) | $ (68,334) | $ (54,568) |  |
Cumulative effect of new accounting principle in period of adoption |  |  |  |  |  |  |  |  |  |  |  | (897) | $ (1,117)
Topic 842 | Accumulated Deficit |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative effect of new accounting principle in period of adoption |  |  |  |  |  |  |  |  |  |  |  | $ 900 |
Sanofi |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 22,680 | 13,516 | 12,258 |  |
Pfizer SB-525 |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 39,359 | $ 37,810 | $ 17,008 |  |
Pfizer SB-525 | Change in collaboration agreement scope | Collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 5,700 |  |  |  |
Net loss |  |  |  |  |  |  |  |  | $ 5,700 |  |  |  |
Earnings per share, basic | $ / shares |  |  |  |  |  |  |  |  | $ 0.05 |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated useful lives of related assets |  |  |  |  |  |  |  |  | 3 years |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated useful lives of related assets |  |  |  |  |  |  |  |  | 5 years |  |  |  |

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