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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Operating Activities: |  |  |
Net loss | $ (95,419) | $ (68,889) | $ (54,568)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |  |
Depreciation and amortization | 3,930 | 2,359 | 1,498
Amortization of discount on marketable securities | (4,708) | (5,829) | (673)
Amortization and other changes in right-of-use assets | (5,677) |  |
Gain on free shares | (488) | 0 | 0
Net loss on disposal of property and equipment | 68 | 0 | 12
Stock-based compensation | 19,330 | 14,677 | 9,089
Net loss on lease termination | 218 | 0 | 0
Build-to-suit leases |  | 966 | 80
Net changes in operating assets and liabilities: |  |  |
Interest receivable | (307) | (135) | (16)
Accounts receivable | (32,236) | (1,330) | 1,629
Prepaid expenses and other assets | (6,660) | (2,828) | (669)
Accounts payable and accrued liabilities | (4,192) | (6,372) | 3,219
Accrued compensation and employee benefits | 4,129 | 2,604 | 2,594
Deferred revenues | (35,693) | 99,364 | 48,984
Long-term portion of lease liabilities | (1,800) |  |
Other non-current liabilities | 3,749 | 1,963 | 0
Net cash (used in) provided by operating activities | (144,402) | 36,550 | 11,179
Investing Activities: |  |  |
Acquisition, net of cash acquired | 0 | (75,647) | 0
Purchases of marketable securities | (443,711) | (451,239) | (252,328)
Maturities of marketable securities | 404,847 | 391,845 | 178,675
Purchases of property and equipment | (20,675) | (43,065) | (3,751)
Purchase of additional Sangamo France shares | (262) | 0 | 0
Net cash used in investing activities | (59,801) | (178,106) | (77,404)
Financing Activities: |  |  |
Proceeds from public offering of common stock, net of issuance costs | 136,308 | 215,758 | 81,573
Taxes paid related to net share settlement of equity awards | (422) | (254) | (654)
Proceeds from issuance of common stock under employee stock purchase plan | 2,044 | 1,484 | 818
Proceeds from exercise of stock options and restricted stock units | 4,099 | 14,721 | 15,753
Net cash provided by financing activities | 142,029 | 231,709 | 97,490
Effects of exchange rate changes on cash and cash equivalents | 184 | 439 | 0
Net (decrease) increase in cash, cash equivalents, and restricted cash | (61,990) | 90,592 | 31,265
Cash, cash equivalents, and restricted cash, beginning of period | 143,918 | 53,326 | 22,061
Cash, cash equivalents, and restricted cash, end of period | 81,928 | 143,918 | 53,326
Supplemental disclosure of non-cash investing activities: |  |  |
Non-controlling interest for acquisition | 0 | 1,313 | 0
Right-of-use assets obtained in exchange for lease obligations | 31,291 | 0 | 0
Property and Equipment |  |  |
Supplemental disclosure of non-cash investing activities: |  |  |
Capital expenditures included in unpaid liabilities | 2,114 | 4,953 | 1,214
Build-to-Suit Leases |  |  |
Supplemental disclosure of non-cash investing activities: |  |  |
Capital expenditures included in unpaid liabilities | $ 0 | $ 2,950 | $ 20,793

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