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Organization and Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2019
Accounting Policies [Abstract] |
Schedule of Revenue from Strategic Partnering Collaboration Agreements and Research Activity Grants as a Percentage of Total Revenues | Revenues from collaboration agreements and research activity grants as a percentage of total revenues were as follows:
| Year Ended December 31, |  |  |  |
| 2019 |  | 2018 |  | 2017
Pfizer Inc. | 40 | % |  | 47 | % |  | 47 | %
Kite Pharma, Inc. | 34 | % |  | 30 | % |  | — |
Sanofi Genzyme | 22 | % |  | 16 | % |  | 34 | %
Schedule of Cash and Cash Equivalents | A reconciliation of cash, cash equivalents and restricted cash reported within the Consolidated Balance Sheets to the amounts reported within the accompanying Consolidated Statements of Cash Flows is as follows (in thousands):
| As of December 31, |  |  |  |  |  |
| 2019 |  | 2018 |  | 2017 |  |
Cash and cash equivalents | $ | 80,428 |  |  | $ | 140,418 |  |  | $ | 49,826 |  |  |
Non-current restricted cash | 1,500 |  |  | 3,500 |  |  | 3,500 |  |  |
Cash, cash equivalents and restricted cash as reported within the Consolidated Statements of Cash Flows | $ | 81,928 |  |  | $ | 143,918 |  |  | $ | 53,326 |  |  |
Restrictions on Cash and Cash Equivalents | A reconciliation of cash, cash equivalents and restricted cash reported within the Consolidated Balance Sheets to the amounts reported within the accompanying Consolidated Statements of Cash Flows is as follows (in thousands):
| As of December 31, |  |  |  |  |  |
| 2019 |  | 2018 |  | 2017 |  |
Cash and cash equivalents | $ | 80,428 |  |  | $ | 140,418 |  |  | $ | 49,826 |  |  |
Non-current restricted cash | 1,500 |  |  | 3,500 |  |  | 3,500 |  |  |
Cash, cash equivalents and restricted cash as reported within the Consolidated Statements of Cash Flows | $ | 81,928 |  |  | $ | 143,918 |  |  | $ | 53,326 |  |  |
Schedule of New Accounting Pronouncements and Changes in Accounting Principles | The impact of the adoption of ASC Topic 842 on the accompanying Consolidated Balance Sheet as of January 1, 2019 was as follows (in thousands):
| December 31, 2018 |  | Adjustments Due to the Adoption of ASC Topic 842 |  | January 1, 2019
Assets: |  |  |  |  |
Property and equipment, net | $ | 78,723 |  |  | $ | (62,500) |  |  | $ | 16,223 |
Operating lease right-of-use assets | — |  |  | 8,753 |  |  | 8,753 |
Prepaid rent | — |  |  | 36,025 |  |  | 36,025 |
Liabilities: |  |  |  |  |
Operating lease liabilities - current(1) | — |  |  | 1,408 |  |  | 1,408 |
Deferred rent(1) | 271 |  |  | (271) |  |  | — |
Build-to-suit lease obligation(2) | 27,689 |  |  | (27,689) |  |  | — |
Operating lease liabilities - long-term(2) | — |  |  | 7,933 |  |  | 7,933 |
Accumulated deficit | (562,696) |  |  | 897 |  |  | (561,799) |
___________________ (1) Operating lease liabilities – current and deferred rent are included in accounts payable and accrued liabilities on the Consolidated Balance Sheets. (2) Build-to-suit lease obligation and operating lease liabilities – long-term are included in long-term portion of lease liabilities on the Consolidated Balance Sheets.

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