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Other Balance Sheet Details | 12 Months Ended
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Dec. 31, 2019
Balance Sheet Related Disclosures [Abstract] |
Supplemental Balance Sheet Disclosures | NOTE 6 – OTHER BALANCE SHEET DETAILS Property and Equipment, Net Property and equipment, net consist of the following (in thousands):
| December 31, |  |
| 2019 |  | 2018
Laboratory equipment | $ | 17,179 |  |  | $ | 11,466 |
Furniture and fixtures | 4,639 |  |  | 3,840 |
Leasehold improvements | 13,888 |  |  | 3,640 |
Buildings | — |  |  | 3,876 |
Construction in progress | 5,901 |  |  | 65,211 |
| 41,607 |  |  | 88,033 |
Less: accumulated depreciation and amortization | (11,681) |  |  | (9,310) |
Property and equipment, net | $ | 29,926 |  |  | $ | 78,723 |
Depreciation and amortization expense was $3.9 million in 2019, $2.4 million in 2018 and $1.5 million in 2017. Intangible Assets The changes in intangible assets were as follows (in thousands):
| December 31, |  |
| 2019 |  | 2018
Balance, beginning of year | $ | 54,243 |  |  | $ | — |
Indefinite-lived assets - IPR&D | — |  |  | 55,019 |
Foreign currency translation adjustment | (1,087) |  |  | (776) |
Balance, end of year | $ | 53,156 |  |  | $ | 54,243 |
Goodwill The changes in goodwill were as follows (in thousands):
| December 31, |  |
| 2019 |  | 2018
Balance, beginning of year | $ | 40,044 |  |  | $ | 1,585 |
Goodwill acquired | — |  |  | 38,995 |
Foreign currency translation adjustment | (771) |  |  | (536) |
Balance, end of year | $ | 39,273 |  |  | $ | 40,044 |
Accounts Payable and Accrued Liabilities Accounts payable and accrued liabilities consist of the following (in thousands):
| December 31, |  |
| 2019 |  | 2018
Accounts payable | $ | 6,671 |  |  | $ | 3,355 |
Accrued research and development expenses | 4,102 |  |  | 10,999 |
Operating lease liabilities - current | 3,214 |  |  | — |
Accrued professional fees | 1,118 |  |  | 1,930 |
Deferred rent | — |  |  | 204 |
Other | 2,451 |  |  | 4,969 |
Total accounts payable and accrued liabilities | $ | 17,556 |  |  | $ | 21,457 |

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- Definition The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -URI http://asc.fasb.org/topic&trid=2122208 + Details
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