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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Income Tax Disclosure [Abstract]

Summary of Domestic and Foreign Components of Loss Before Income Taxes

The domestic and foreign components of loss before income taxes were as follows (in thousands):

			Year Ended December 31,
			2019						2018						2017
Domestic			$	(77,354)					$	(65,695)					$	(54,568)
Foreign			(18,065)						(3,194)						—
Loss before income taxes			$	(95,419)					$	(68,889)					$	(54,568)

Summary of Benefit for Income Taxes

The benefit for income taxes consisted of the following (in thousands):

			Year Ended December 31,
			2019						2018						2017
Benefit for income taxes:
Current:
Federal			$	—					$	—					$	—
State			—						—						—
Foreign			—						—						—
Subtotal			—						—						—
Deferred:
Federal			—						—						—
State			—						—						—
Foreign			—						—						—
Subtotal			—						—						—
Income tax benefit			$	—					$	—					$	—

Schedule of Difference Between Benefit for Income Taxes and Federal Statutory Income Tax Rate

The difference between the benefit for income taxes and the amount computed by applying the federal statutory income tax rate to loss before taxes is explained as follows (in thousands):

			Year Ended December 31,
			2019						2018						2017
Tax at federal statutory rate(1)			$	(20,038)					$	(14,467)					$	(18,553)
State taxes, net			(9,597)						(2,849)						795
Federal rate change			—						—						53,045
Foreign rate differential			(665)						(177)						—
Non-deductible stock-based compensation			2,817						(2,729)						2,120
Research credits			(3,429)						(1,005)						(869)
Change in valuation allowance			29,655						20,271						(36,575)
Other			1,257						956						37
Income tax benefit			$	—					$	—					$	—

___________________

(1)For the year ended December 31, 2017 the statutory tax rate was 35%. For the years ended December 31, 2018 and 2019, as a result of Tax Reform, the statutory tax rate was decreased to 21%.

Schedule of Company's Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

			December 31,
			2019						2018
Assets:
Deferred tax assets:
Net operating loss carryforwards			$	133,765					$	138,896
Research and development tax credit carryforwards			21,459						16,829
Stock-based compensation			4,194						3,801
Deferred revenue			32,171						3,191
Fixed assets			11,282						—
Lease liability			11,722						—
Build to suit lease liability			—						6,400
Accruals and reserves			675						—
Other			151						604
Total deferred tax asset			215,419						169,721
Valuation allowance			187,724						158,150
Net deferred tax assets			27,695						11,571
Liabilities:
Intangible assets			(13,609)						(14,100)
Operating lease right-of-use assets			(20,656)						—
Fixed assets			—						(4,176)
Net deferred tax liability			(34,265)						(18,276)
Total deferred tax liability			$	(6,570)					$	(6,705)

Summary of Activity Related to Company's Unrecognized Tax Benefits

The following table summarizes the activity related to the Company’s unrecognized tax benefits (in thousands):

			December 31,
			2019						2018						2017
Beginning balance			$	6,288					$	5,659					$	5,045
Additions based on tax positions related to the current year			5,393						636						622
Additions for tax positions of prior years			(51)						(7)						(8)
Reductions for tax positions of prior years			—						—						—
Ending balance			$	11,630					$	6,288					$	5,659

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of unrecognized tax benefits for which a material change is reasonably possible in the next twelve months, typically including the nature of the uncertainty, the event(s) that could cause a material change, and an estimate of the range of the reasonably possible change or a statement that an estimate of the range cannot be made. An unrecognized tax benefit is the difference between a tax position taken in a tax return and the amounts recognized in the financial statements for which it is more likely than not, based on the technical merits of the position, that the tax position will not be sustained upon examination.

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