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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2019 USD ($) shares	Sep. 30, 2019 USD ($)	Jun. 30, 2019 USD ($)	Mar. 31, 2019 USD ($)	Dec. 31, 2018 USD ($) shares	Sep. 30, 2018 USD ($)	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2019 USD ($) segment $ / shares shares	Dec. 31, 2018 USD ($) shares	Dec. 31, 2017 USD ($) shares	Jan. 01, 2019 USD ($)	Jan. 01, 2018 USD ($)
Organization and Summary of Significant Accounting Policies [Line Items]
Revenues	$ 54,851	$ 21,958	$ 17,548	$ 8,071	$ 26,837	$ 23,562	$ 21,416	$ 12,637	$ 102,428	$ 84,452	$ 36,567
Net loss	4,501	$ (27,361)	$ (30,356)	$ (42,203)	$ (19,219)	$ (12,843)	$ (16,640)	$ (20,187)	(95,419)	$ (68,889)	$ (54,568)
Letter of credit	$ 1,500								$ 1,500
Stock options and RSUs outstanding (in shares) | shares	10,750,550				9,048,793				10,750,550	9,048,793	8,367,628
Number of operating segments | segment									1
Cumulative effect of new accounting principle in period of adoption												$ (897)	$ (1,117)
Accumulated Deficit
Organization and Summary of Significant Accounting Policies [Line Items]
Net loss									$ (95,186)	$ (68,334)	$ (54,568)
Cumulative effect of new accounting principle in period of adoption												(897)	$ (1,117)
Topic 842 | Accumulated Deficit
Organization and Summary of Significant Accounting Policies [Line Items]
Cumulative effect of new accounting principle in period of adoption												$ 900
Sanofi
Organization and Summary of Significant Accounting Policies [Line Items]
Revenues									22,680	13,516	12,258
Pfizer SB-525
Organization and Summary of Significant Accounting Policies [Line Items]
Revenues									39,359	$ 37,810	$ 17,008
Pfizer SB-525 | Change in collaboration agreement scope | Collaborative arrangement
Organization and Summary of Significant Accounting Policies [Line Items]
Revenues									5,700
Net loss									$ 5,700
Earnings per share, basic | $ / shares									$ 0.05
Minimum
Organization and Summary of Significant Accounting Policies [Line Items]
Estimated useful lives of related assets									3 years
Maximum
Organization and Summary of Significant Accounting Policies [Line Items]
Estimated useful lives of related assets									5 years

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