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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Operating Activities:      
Net loss $ (95,419) $ (68,889) $ (54,568)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:      
Depreciation and amortization 3,930 2,359 1,498
Amortization of discount on marketable securities (4,708) (5,829) (673)
Amortization and other changes in right-of-use assets (5,677)    
Gain on free shares (488) 0 0
Net loss on disposal of property and equipment 68 0 12
Stock-based compensation 19,330 14,677 9,089
Net loss on lease termination 218 0 0
Build-to-suit leases   966 80
Net changes in operating assets and liabilities:      
Interest receivable (307) (135) (16)
Accounts receivable (32,236) (1,330) 1,629
Prepaid expenses and other assets (6,660) (2,828) (669)
Accounts payable and accrued liabilities (4,192) (6,372) 3,219
Accrued compensation and employee benefits 4,129 2,604 2,594
Deferred revenues (35,693) 99,364 48,984
Long-term portion of lease liabilities (1,800)    
Other non-current liabilities 3,749 1,963 0
Net cash (used in) provided by operating activities (144,402) 36,550 11,179
Investing Activities:      
Acquisition, net of cash acquired 0 (75,647) 0
Purchases of marketable securities (443,711) (451,239) (252,328)
Maturities of marketable securities 404,847 391,845 178,675
Purchases of property and equipment (20,675) (43,065) (3,751)
Purchase of additional Sangamo France shares (262) 0 0
Net cash used in investing activities (59,801) (178,106) (77,404)
Financing Activities:      
Proceeds from public offering of common stock, net of issuance costs 136,308 215,758 81,573
Taxes paid related to net share settlement of equity awards (422) (254) (654)
Proceeds from issuance of common stock under employee stock purchase plan 2,044 1,484 818
Proceeds from exercise of stock options and restricted stock units 4,099 14,721 15,753
Net cash provided by financing activities 142,029 231,709 97,490
Effects of exchange rate changes on cash and cash equivalents 184 439 0
Net (decrease) increase in cash, cash equivalents, and restricted cash (61,990) 90,592 31,265
Cash, cash equivalents, and restricted cash, beginning of period 143,918 53,326 22,061
Cash, cash equivalents, and restricted cash, end of period 81,928 143,918 53,326
Supplemental disclosure of non-cash investing activities:      
Non-controlling interest for acquisition 0 1,313 0
Right-of-use assets obtained in exchange for lease obligations 31,291 0 0
Property and Equipment      
Supplemental disclosure of non-cash investing activities:      
Capital expenditures included in unpaid liabilities 2,114 4,953 1,214
Build-to-Suit Leases      
Supplemental disclosure of non-cash investing activities:      
Capital expenditures included in unpaid liabilities $ 0 $ 2,950 $ 20,793