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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2020 | Sep. 30, 2019
Operating Activities: |  |
Net loss | $ (80,447) | $ (99,920)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |
Depreciation and amortization | 3,999 | 2,742
Amortization of discount on marketable securities | (1,344) | (3,715)
Amortization and other changes in operating lease right-of-use assets | 5,706 | 3,796
Gain on free shares | (31) | (488)
Stock-based compensation | 19,066 | 14,091
Loss on disposal of property and equipment | 197 | 0
Net loss on lease termination | 0 | 218
Other | 0 | (29)
Net changes in operating assets and liabilities: |  |
Interest receivable | (140) | (305)
Accounts receivable | (2,578) | (17,280)
Prepaid expenses and other assets | (9,098) | (4,734)
Accounts payable and accrued liabilities | 1,336 | (1,753)
Accrued compensation and employee benefits | 4,186 | 1,608
Deferred revenues | 235,551 | (20,477)
Long-term portion of lease liabilities | (2,760) | (920)
Other non-current liabilities | 527 | 3,580
Net cash provided by (used in) operating activities | 174,170 | (123,586)
Investing Activities: |  |
Purchases of marketable securities | (335,002) | (321,390)
Maturities of marketable securities | 205,039 | 292,147
Purchases of property and equipment | (10,703) | (13,894)
Purchase of additional shares of Sangamo France | (503) | (262)
Net cash used in investing activities | (141,169) | (43,399)
Financing Activities: |  |
Proceeds from public offering of common stock, net of issuance costs | 0 | 136,308
Proceeds from issuance of common stock in connection with the Biogen collaboration agreement, net of issuance costs | 142,526 | 0
Taxes paid related to net share settlement of equity awards | (573) | (388)
Proceeds from exercise of stock options and restricted stock units | 3,041 | 3,751
Proceeds from exercise of stock options and restricted stock units | 1,187 | 1,139
Net cash provided by financing activities | 146,181 | 140,810
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (217) | 48
Net increase (decrease) in cash, cash equivalents, and restricted cash | 178,965 | (26,127)
Cash, cash equivalents, and restricted cash, beginning of period | 81,928 | 143,918
Cash, cash equivalents, and restricted cash, end of period | 260,893 | 117,791
Supplemental disclosure of non-cash activities: |  |
Property and equipment included in unpaid liabilities | 899 | 4,257
Right-of-use assets obtained in exchange for lease obligations | $ 0 | $ 29,647

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