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Major Customers, Partnerships and Strategic Alliances - Additional Information (Detail) |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended | 13 Months Ended | 17 Months Ended | 37 Months Ended | 41 Months Ended | 84 Months Ended |  |
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Jul. 27, 2020 USD ($) | Apr. 05, 2018 USD ($) | Oct. 30, 2020 USD ($) | Sep. 30, 2020 USD ($) | Aug. 31, 2020 USD ($) | May 31, 2020 USD ($) | Apr. 30, 2020 USD ($) $ / shares | Apr. 30, 2020 USD ($) $ / shares shares | Mar. 31, 2020 USD ($) $ / shares | Feb. 29, 2020 USD ($) product_target | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | May 31, 2018 USD ($) | Apr. 30, 2018 USD ($) | Dec. 31, 2017 USD ($) | May 31, 2017 USD ($) | Jan. 31, 2014 USD ($) program | Jan. 31, 2012 USD ($) | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2020 USD ($) product milestone option product_target $ / shares | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2020 USD ($) milestone | Sep. 30, 2020 USD ($) | Dec. 31, 2020 USD ($) | Feb. 28, 2020 | Aug. 31, 2019 USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, maximum number of product targets to replace | product_target |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 |  |  |  |  |  |  |  |  |  |
Issuance costs related to sangamo france acquisition |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |  |  |  |
Agreement termination, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 180 days |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 25,800,000 | $ 57,763,000 | $ 21,553,000 | $ 13,076,000 | $ 54,851,000 | $ 21,958,000 | $ 17,548,000 | $ 8,071,000 | $ 118,192,000 | 102,428,000 | $ 84,452,000 |  |  |  |  |  |  |  |
Other long-term liabilities |  |  |  |  |  |  |  |  |  |  | $ 5,711,000 |  |  |  |  |  |  |  | 7,011,000 |  |  |  | 5,711,000 |  |  |  | 7,011,000 | 5,711,000 |  |  | $ 7,011,000 | $ 7,011,000 | $ 7,011,000 |  | $ 7,011,000 |  |
California Institute for Regenerative Medicine ("CIRM") |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Funds due under the agreement |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other long-term liabilities |  |  |  |  |  |  |  |  |  |  | 5,700,000 |  |  |  |  |  |  |  | 6,400,000 |  |  |  | 5,700,000 |  |  |  | 6,400,000 | 5,700,000 |  |  | 6,400,000 | 6,400,000 | 6,400,000 |  | 6,400,000 |  |
Research grants | California Institute for Regenerative Medicine ("CIRM") |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,200,000 |  |  |  |  |  |  |  |  |  |
Novartis Institutes For Bio Medical Research Inc | Collaboration agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,100,000 |  |  |  |  |  |  |  |  |  |
Novartis Institutes For Bio Medical Research Inc | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from collaborators |  |  |  |  | $ 75,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement transaction price | $ 95,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, license fee | 75,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement estimated reimbursable service costs | 20,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 70,900,000 |  |  |  |  |  |  |  | 70,900,000 |  |  |  | 70,900,000 | 70,900,000 | 70,900,000 |  | 70,900,000 |  |
Collaboration arrangement, commission fee, portion of gross proceeds, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,500,000 |  |  |  |  |  |  |  | 1,500,000 |  |  |  | 1,500,000 | 1,500,000 | 1,500,000 |  | 1,500,000 |  |
Collaborative agreement, percent of initial recognition |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization cost |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |
Novartis Institutes For Bio Medical Research Inc | Collaboration and license agreement | Maximum | Achievement of specified preclinical development clinical development and first commercial sale milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received | 420,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Novartis Institutes For Bio Medical Research Inc | Collaboration and license agreement | Maximum | Achievement of commercial milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received | $ 300,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Biogen MA Inc | Collaboration agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 21,400,000 |  |  |  |  |  |  |  |  |  |
Biogen MA Inc | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from collaborators |  |  |  |  |  | $ 125,000,000.0 |  |  |  | $ 125,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration arrangement, commission fee, portion of gross proceeds, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7,000,000.0 |  |  |  |  |  |  |  | $ 7,000,000.0 |  |  |  | 7,000,000.0 | 7,000,000.0 | 7,000,000.0 |  | 7,000,000.0 |  |
Collaborative agreement, percent of initial recognition |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |  |  |  |  |
Amortization cost |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 400,000 |  |  |  |  |  |  |  |  |  |
Maximum milestone payment receivable |  |  |  |  |  |  |  |  |  | $ 2,370,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of neurological disease gene targets | product_target |  |  |  |  |  |  |  |  |  | 12 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of product targets selected | product_target |  |  |  |  |  |  |  |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of additional neurological disease gene targets | product_target |  |  |  |  |  |  |  |  |  | 9 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Target selection period |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract with customer, asset, after allowance for credit Loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 4,100,000 |  |  |  |  |  |  |  | 4,100,000 |  |  |  | 4,100,000 | 4,100,000 | 4,100,000 |  | 4,100,000 |  |
Biogen MA Inc | Collaboration and license agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration arrangement, research period |  |  |  |  |  |  |  |  |  | 7 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Biogen MA Inc | Collaboration and license agreement | Pre-approval Milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum milestone payment receivable |  |  |  |  |  |  |  |  |  | $ 925,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Biogen MA Inc | Collaboration and license agreement | Sales-based Milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum milestone payment receivable |  |  |  |  |  |  |  |  |  | $ 1,450,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Biogen MA Inc | Stock Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 183,200,000 |  |  |  |  |  |  |  | 183,200,000 |  |  |  | 183,200,000 | 183,200,000 | 183,200,000 |  | 183,200,000 |  |
Sale of stock, number of shares issued in transaction (in shares) | shares |  |  |  |  |  |  |  | 24,420,157 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 9.2137 | $ 9.2137 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consideration received from sale of stock |  |  |  |  |  |  | $ 225,000,000.0 | $ 225,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Agreement restriction expiration period |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Agreement restriction, ownership percentage (less than) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5.00% |
Agreement restriction, percentage of shares held |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50.00% |
Agreement provision, expiration period |  |  |  |  |  |  |  |  |  | 2 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Agreement provision, ownership percentage (less than) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5.00% |
Sale of stock, excess consideration received on transaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 79,600,000 |  |  |  |  |  |  |  |  |  |
Collaboration agreement, equity issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 145,400,000 |  |  |  |  |  |  |  | 145,400,000 |  |  |  | 145,400,000 | 145,400,000 | 145,400,000 |  | 145,400,000 |  |
Issuance costs related to sangamo france acquisition |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Kite Pharma, Inc. ("Kite") |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 28,608,000 | 34,350,000 | 25,517,000 |  |  |  |  |  |  |  |
Kite Pharma, Inc. ("Kite") | Collaboration agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,046,000 | 24,977,000 | 18,545,000 |  |  |  |  |  |  |  |
Kite Pharma, Inc. ("Kite") | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement transaction price |  |  |  |  |  |  |  |  |  |  |  | $ 189,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement estimated reimbursable service costs |  |  |  |  |  |  |  |  |  |  |  | 39,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  | 106,500,000 |  |  |  |  |  |  |  | 81,400,000 |  |  |  | 106,500,000 |  |  |  | $ 81,400,000 | 106,500,000 |  |  | 81,400,000 | 81,400,000 | 81,400,000 |  | 81,400,000 |  |
Milestone payments received |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 150,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial research term of agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6 years |  |  |  |  |  |  |  |  |  |
Number of options to extend initial research term | option |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |
Extended research term of agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 year |  |  |  |  |  |  |  |  |  |
Separate fee for additional term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000,000.0 |  |  |  |  |  |  |  |  |  |
Collaborative arrangement estimated reimbursable service costs for new research plan |  |  |  |  |  |  |  |  |  |  |  | 3,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  | $ 150,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Kite Pharma, Inc. ("Kite") | Collaboration and license agreement | Achievement of specified research, clinical development, regulatory and first commercial sale milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent development and sales-based milestone payments to be received |  | $ 1,260,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Kite Pharma, Inc. ("Kite") | Collaboration and license agreement | Achievement of specified sales-based milestones if annual worldwide net sales of licensed products reach specified levels |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent development and sales-based milestone payments to be received |  | 1,750,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Kite Pharma, Inc. ("Kite") | Collaboration and license agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | $ 3,010,000,000.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer, Giroctocogene Fitelparvovec |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  | 4,000,000.0 |  |  |  |  |  |  |  |  |  |  |  | 4,000,000.0 |  |  |  |  | 4,000,000.0 |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 34,449,000 | 39,359,000 | 37,810,000 |  |  |  |  |  |  |  |
Collaborative arrangement, increase (decrease) in revenue |  |  |  |  |  |  |  |  | $ 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, increase (decrease) in net income (loss) |  |  |  |  |  |  |  |  | $ 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer, Giroctocogene Fitelparvovec | Phase Three Clinical Trial |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  | $ 30,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative compensation earned |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 30,000,000.0 |  |  |  |  |  |  |  | 30,000,000.0 |  |  |  | 30,000,000.0 | 30,000,000.0 | 30,000,000.0 |  | 30,000,000.0 |  |
Pfizer, Giroctocogene Fitelparvovec | Collaboration agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,700,000 |  |  |  |  |  |  |  | 3,111,000 | 15,697,000 | 37,810,000 |  |  |  |  |  |  |  |
Contract with customer, liability, cumulative catch-up adjustment to revenue, change in measure of progress |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer, Giroctocogene Fitelparvovec | Amended collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Recognition of milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,300,000 |  |  |  | 25,000,000.0 |  |  |  |  |  |
Pfizer C9ORF72 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,000,000.0 |  |  |  |
Number of products approved | milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Number of milestones included in transaction price | milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |
Agreement termination, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15 years |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12,985,000 | 1,827,000 | 2,188,000 |  |  |  |  |  |  |  |
Pfizer C9ORF72 | Collaboration agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7,985,000 | 1,827,000 | 2,188,000 |  |  |  |  |  |  |  |
Pfizer C9ORF72 | C9ORF72 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  | 8,000,000.0 |  |  |  |  |  |  |  |  |  |  |  | 8,000,000.0 |  |  |  |  | 8,000,000.0 |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer C9ORF72 | C9ORF72 | Maximum | Achievement of specified preclinical development clinical development and first commercial sale milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer C9ORF72 | C9ORF72 | Maximum | Achievement of commercial milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 90,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sanofi |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 20,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of products approved | product |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,322,000 | 22,680,000 | 13,516,000 |  |  |  |  |  |  |  |
Collaborative arrangement, increase (decrease) in revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,200,000) |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, increase (decrease) in net income (loss) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,200,000 |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, net Income (loss) per share | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (0.02) |  |  |  |  |  |  |  |  |  |
Number of research programs | program |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sanofi | Collaboration agreements |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 298,000 | 3,494,000 | 4,013,000 |  |  |  |  |  |  |  |
Sanofi | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement transaction price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 93,300,000 |  |  |  |  |  |  |  |  |  |
Collaborative arrangement estimated reimbursable service costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 59,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  | 1,700,000 |  |  |  |  |  |  |  | 1,200,000 |  |  |  | 1,700,000 |  |  |  | 1,200,000 | 1,700,000 |  |  | 1,200,000 | 1,200,000 | $ 1,200,000 |  | 1,200,000 |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 20,000,000.0 |  |  |  |  |  |  |  |  |  |
Number of milestones included in transaction price | milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Recognition of milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  | 5,800,000 |  |  | 7,200,000 |  |
Sanofi | Collaboration and license agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 276,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sanofi | Collaboration and license agreement | Maximum | Achievement of specified clinical development and regulatory milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 115,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sanofi | Collaboration and license agreement | Maximum | Achievement of specified sales milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 160,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sanofi | Collaboration and license agreement | Milestone One |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,000,000.0 |  |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 6,000,000.0
Sanofi | Collaboration and license agreement | Milestone Two |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  |  |  |  |  |  |  |  |  | $ 7,500,000 |  |  |  |  |  |  |  | 7,500,000 |  |  |  | $ 7,500,000 |  |  |  | 7,500,000 | 7,500,000 |  |  | 7,500,000 | 7,500,000 | 7,500,000 |  | 7,500,000 |  |
Sanofi | Collaboration and license agreement | Milestone Three |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 13,500,000 |  |  |  |  |  |  |  | 13,500,000 |  |  |  | 13,500,000 | 13,500,000 | 13,500,000 |  | 13,500,000 |  |
Shire AG |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 | $ 0 | $ 0 |  |  |  |  |  |  |  |
Shire AG | Collaboration and license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 13,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Agreement termination, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 90 days |  |  |  |  |  |  |  |  |  |
Recognition of milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000,000.0 |  |  |  |  |  |  |
Pfizer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement transaction price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 134,000,000.0 |  |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 70,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of products approved | product |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Research service fees |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 79,000,000.0 |  |  |  |  |  |  |  |  |  |
Collaborative arrangement reimbursable service costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 55,000,000.0 |  |  |  |  |  |  |  | $ 55,000,000.0 |  |  |  | $ 55,000,000.0 | $ 55,000,000.0 | $ 55,000,000.0 |  | $ 55,000,000.0 |  |
Agreement termination, term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15 years |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, increase (decrease) in revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,800,000 |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, increase (decrease) in net income (loss) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,800,000 |  |  |  |  |  |  |  |  |  |
Collaborative arrangement, net Income (loss) per share | $ / shares |  |  |  |  |  |  |  |  | $ (0.02) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.06 |  |  |  |  |  |  |  |  |  |
Pfizer | Maximum | Achievement of specified clinical development intellectual property and regulatory milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 208,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer | Maximum | Achievement of first commercial sale milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 475,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer | Other products | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 175,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer | C9ORF72 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  | $ 5,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangement transaction price |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 17,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,000,000.0 |  |  |  | $ 5,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pfizer | Giroctocogene Fitelparvovec |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 55,000,000.0 |  |  |
Number of milestones included in transaction price | milestone |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Pfizer | Giroctocogene Fitelparvovec | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential amount to be funded for achievement of specified commercialized and sales milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 266,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 300,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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