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Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Oct. 31, 2009 | Dec. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2007
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued |  |  |  |  |  |  |  |  |  | $ 142,526 | $ 136,308 | $ 215,758 |
Revenues |  | $ 25,800 | $ 57,763 | $ 21,553 | $ 13,076 | $ 54,851 | $ 21,958 | $ 17,548 | $ 8,071 | 118,192 | 102,428 | 84,452 |
Sigma-Aldrich Corporation |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Developed laboratory research reagents, research services period |  |  |  |  |  |  |  |  |  |  |  |  | 3 years
Deferred revenue | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |
Common stock issued | $ 4,900 |  |  |  |  |  |  |  |  |  |  |  |
Public offering, common stock shares issued | 636,133 |  |  |  |  |  |  |  |  |  |  |  |
Reduced royalty rate | 10.50% |  |  |  |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received | $ 25,000 |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  | $ 500 | $ 600 | $ 500 |
Sigma-Aldrich Corporation | License agreement terms |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues under agreement | 5,000 |  |  |  |  |  |  |  |  |  |  |  |
Sigma-Aldrich Corporation | License fee revenues |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue | $ 15,100 |  |  |  |  |  |  |  |  |  |  |  |

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