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Cash Equivalents and Marketable Securities - Summary of Cash Equivalents and Available-for-Sale Securities (Detail) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
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Debt Securities, Available-for-sale [Line Items] |  |
Cash and cash equivalents, at carrying value, total | $ 131,329 | $ 80,428
Available-for-sale securities, amortized cost | 560,575 | 303,546
Available-for-sale securities, gross unrealized gains | 86 | 351
Available-for-sale securities, gross unrealized (Losses) | (37) | (19)
Available-for-sale securities, estimated fair value | 560,624 | 303,878
Total cash equivalents and available-for-sale securities, amortized cost | 613,740 | 337,040
Total cash equivalents and available-for-sale securities, gross unrealized gains | 86 | 352
Total cash equivalents and available-for-sale securities, gross unrealized (losses) | (37) | (19)
Total cash equivalents and available-for-sale securities, estimated fair value | 613,789 | 337,373
Money market funds |  |
Debt Securities, Available-for-sale [Line Items] |  |
Cash and cash equivalents, at carrying value, total | 53,165 | 30,496
Cash equivalents, gross unrealized gains | 0 | 0
Cash and cash equivalents accumulated gross unrealized loss before tax | 0 | 0
Cash equivalents, estimated fair value | 53,165 | 30,496
Commercial paper |  |
Debt Securities, Available-for-sale [Line Items] |  |
Cash and cash equivalents, at carrying value, total |  | 2,998
Cash equivalents, gross unrealized gains |  | 1
Cash and cash equivalents accumulated gross unrealized loss before tax |  | 0
Cash equivalents, estimated fair value |  | 2,999
Available-for-sale securities, amortized cost | 213,500 | 155,230
Available-for-sale securities, gross unrealized gains | 41 | 145
Available-for-sale securities, gross unrealized (Losses) | (8) | (7)
Available-for-sale securities, estimated fair value | 213,533 | 155,368
Cash equivalents: |  |
Debt Securities, Available-for-sale [Line Items] |  |
Cash and cash equivalents, at carrying value, total | 53,165 | 33,494
Cash equivalents, gross unrealized gains | 0 | 1
Cash and cash equivalents accumulated gross unrealized loss before tax | 0 | 0
Cash equivalents, estimated fair value | 53,165 | 33,495
Corporate debt securities |  |
Debt Securities, Available-for-sale [Line Items] |  |
Available-for-sale securities, amortized cost | 59,575 | 94,905
Available-for-sale securities, gross unrealized gains | 16 | 115
Available-for-sale securities, gross unrealized (Losses) | (17) | (3)
Available-for-sale securities, estimated fair value | 59,574 | 95,017
Certificates of deposit |  |
Debt Securities, Available-for-sale [Line Items] |  |
Available-for-sale securities, amortized cost | 12,311 |
Available-for-sale securities, gross unrealized gains | 0 |
Available-for-sale securities, gross unrealized (Losses) | 0 |
Available-for-sale securities, estimated fair value | 12,311 |
U.S. government-sponsored entity debt securities |  |
Debt Securities, Available-for-sale [Line Items] |  |
Available-for-sale securities, amortized cost | 257,284 | 53,411
Available-for-sale securities, gross unrealized gains | 19 | 91
Available-for-sale securities, gross unrealized (Losses) | (5) | (9)
Available-for-sale securities, estimated fair value | 257,298 | $ 53,493
Asset-backed securities |  |
Debt Securities, Available-for-sale [Line Items] |  |
Available-for-sale securities, amortized cost | 17,905 |
Available-for-sale securities, gross unrealized gains | 10 |
Available-for-sale securities, gross unrealized (Losses) | (7) |
Available-for-sale securities, estimated fair value | $ 17,908 |

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