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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating Activities: |  |  |
Net loss | $ (121,122) | $ (95,419) | $ (68,889)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 5,682 | 3,930 | 2,359
Amortization of discount on marketable securities | (825) | (4,708) | (5,829)
Amortization and other changes in right-of-use assets | (7,687) | (5,677) | 0
Gain on free shares | (63) | (488) | 0
Net loss on disposal of property and equipment | 222 | 68 | 0
Stock-based compensation | 25,708 | 19,330 | 14,677
Net loss on lease termination | 0 | 218 | 0
Build-to-suit leases |  | 0 | 966
Net changes in operating assets and liabilities: |  |  |
Interest receivable | (353) | (307) | (135)
Accounts receivable | 31,685 | (32,236) | (1,330)
Prepaid expenses and other assets | (10,411) | (6,660) | (2,828)
Accounts payable and other accrued liabilities | 10,703 | (4,192) | (6,372)
Accrued compensation and employee benefits | 6,877 | 4,129 | 2,604
Deferred revenues | 216,546 | (35,693) | 99,364
Long-term portion of lease liabilities | (3,761) | (1,800) | 0
Other non-current liabilities | 1,300 | 3,749 | 1,963
Net cash provided by (used in) operating activities | 169,875 | (144,402) | 36,550
Investing Activities: |  |  |
Acquisition, net of cash acquired | 0 | 0 | (75,647)
Purchases of marketable securities | (570,779) | (443,711) | (451,239)
Maturities of marketable securities | 314,570 | 404,847 | 391,845
Purchases of property and equipment | (14,714) | (20,675) | (43,065)
Purchase of additional Sangamo France shares | (704) | (262) | 0
Net cash used in investing activities | (271,627) | (59,801) | (178,106)
Financing Activities: |  |  |
Proceeds from public offering of common stock, net of issuance costs | 0 | 136,308 | 215,758
Proceeds from issuance of common stock in connection with the Biogen collaboration agreement, net of issuance costs | 142,526 | 0 | 0
Taxes paid related to net share settlement of equity awards | (765) | (422) | (254)
Proceeds from issuance of common stock under employee stock purchase plan | 2,015 | 2,044 | 1,484
Proceeds from exercise of stock options and restricted stock units | 9,324 | 4,099 | 14,721
Net cash provided by financing activities | 153,100 | 142,029 | 231,709
Effect of exchange rate changes on cash and cash equivalents | (447) | 184 | 439
Net increase (decrease) in cash, cash equivalents, and restricted cash | 50,901 | (61,990) | 90,592
Cash, cash equivalents, and restricted cash, beginning of period | 81,928 | 143,918 | 53,326
Cash, cash equivalents, and restricted cash, end of period | 132,829 | 81,928 | 143,918
Supplemental cash flow disclosures: |  |  |
Non-controlling interest for acquisition | 0 | 0 | 1,313
Right-of-use assets obtained in exchange for lease obligations | 1,333 | 31,291 | 0
Property and Equipment |  |  |
Supplemental cash flow disclosures: |  |  |
Capital expenditures included in unpaid liabilities | 4,569 | 2,114 | 4,953
Build-to-Suit Leases |  |  |
Supplemental cash flow disclosures: |  |  |
Capital expenditures included in unpaid liabilities | $ 0 | $ 0 | $ 2,950

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