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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2020 USD ($) shares | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) shares | Sep. 30, 2019 USD ($) | Jun. 30, 2019 USD ($) | Mar. 31, 2019 USD ($) | Dec. 31, 2020 USD ($) segment $ / shares shares | Dec. 31, 2019 USD ($) $ / shares shares | Dec. 31, 2018 USD ($) shares
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues | $ 25,800,000 | $ 57,763,000 | $ 21,553,000 | $ 13,076,000 | $ 54,851,000 | $ 21,958,000 | $ 17,548,000 | $ 8,071,000 | $ 118,192,000 | $ 102,428,000 | $ 84,452,000
Net loss | (40,675,000) | $ (1,508,000) | $ (35,965,000) | $ (42,974,000) | $ 4,501,000 | $ (27,361,000) | $ (30,356,000) | $ (42,203,000) | (121,122,000) | $ (95,419,000) | $ (68,889,000)
Goodwill and intangible asset impairment |  |  |  |  |  |  |  |  | 0 |  |
Impairment of long-lived assets held-for-use |  |  |  |  |  |  |  |  | 0 |  |
Letter of credit | $ 1,500,000 |  |  |  |  |  |  |  | $ 1,500,000 |  |
Stock options and RSUs outstanding (in shares) | shares | 14,237,871 |  |  |  | 10,750,550 |  |  |  | 14,237,871 | 10,750,550 | 9,048,793
Number of operating segments | segment |  |  |  |  |  |  |  |  | 1 |  |
Pfizer SB-525 | Change in collaboration agreement scope | Collaborative arrangement |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | $ 8,900,000 | $ 5,700,000 |
Net loss |  |  |  |  |  |  |  |  | $ 8,900,000 | $ 5,700,000 |
Earnings per share, basic (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 0.06 | $ 0.05 |
Minimum |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Estimated useful lives of related assets |  |  |  |  |  |  |  |  | 3 years |  |
Maximum |  |  |  |  |  |  |  |  |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Estimated useful lives of related assets |  |  |  |  |  |  |  |  | 5 years |  |

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