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Other Balance Sheet Details | 12 Months Ended
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Dec. 31, 2020
Balance Sheet Related Disclosures [Abstract] |
Other Balance Sheet Details | OTHER BALANCE SHEET DETAILS Property and Equipment, Net Property and equipment, net consist of the following (in thousands):
| December 31,
| 2020 |  | 2019
Laboratory equipment | $ | 24,737 |  |  | $ | 17,179 |
Furniture and fixtures | 4,870 |  |  | 4,639 |
Leasehold improvements | 15,953 |  |  | 13,888 |
Manufacturing equipment | 1,089 |  |  | — |
Construction in progress | 12,091 |  |  | 5,901 |
| 58,740 |  |  | 41,607 |
Less: accumulated depreciation and amortization | (17,416) |  |  | (11,681) |
Property and equipment, net | $ | 41,324 |  |  | $ | 29,926 |
Depreciation and amortization expense was $5.7 million in 2020, $3.9 million in 2019 and $2.4 million in 2018. Intangible Assets The changes in intangible assets were as follows (in thousands):
| December 31,
| 2020 |  | 2019
Balance at beginning of year | $ | 53,156 |  |  | $ | 54,243 |
Foreign currency translation adjustment | 4,972 |  |  | (1,087) |
Balance at end of year | $ | 58,128 |  |  | $ | 53,156 |
Goodwill The changes in goodwill were as follows (in thousands):
| December 31,
| 2020 |  | 2019
Balance at beginning of year | $ | 39,273 |  |  | $ | 40,044 |
Foreign currency translation adjustment | 3,525 |  |  | (771) |
Balance at end of year | $ | 42,798 |  |  | $ | 39,273 |
Other Accrued Liabilities Other accrued liabilities consist of the following (in thousands):
| December 31,
| 2020 |  | 2019
Customer advance | $ | 5,000 |  |  | $ | — |
Accrued research and development expenses | 4,257 |  |  | 4,102 |
Operating lease liabilities – current | 3,690 |  |  | 3,214 |
Accrued professional fees | 1,532 |  |  | 1,118 |
Other | 4,133 |  |  | 2,451 |
Total other accrued liabilities | $ | 18,612 |  |  | $ | 10,885 |

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- Definition The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -URI http://asc.fasb.org/topic&trid=2122208 + Details
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