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MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Sanofi S.A. (Detail) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Aug. 31, 2019 USD ($) | Jan. 31, 2014 USD ($) program | Sep. 30, 2021 USD ($) $ / shares | Sep. 30, 2020 USD ($) $ / shares | Sep. 30, 2021 USD ($) milestone product $ / shares | Sep. 30, 2020 USD ($) $ / shares | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues |  |  | $ 28,563 | $ 57,763 | $ 82,715 | $ 92,392 |  |
Net loss |  |  | $ (47,688) | $ (1,508) | $ (140,801) | $ (80,447) |  |
Earnings per share, diluted (in dollars per share) | $ / shares |  |  | $ (0.33) | $ (0.01) | $ (0.98) | $ (0.61) |  |
Earnings per share, basic (in dollars per share) | $ / shares |  |  | $ (0.33) | $ (0.01) | $ (0.98) | $ (0.61) |  |
Sanofi S.A. |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Number of research programs | program |  | 2 |  |  |  |  |  |
Agreement termination, term |  |  |  |  | 180 days |  |  |
Revenues under agreement |  | $ 20,000 |  |  |  |  |  |
Milestone revenue receivable |  |  | $ 6,000 |  | $ 6,000 |  |  |
Number of products approved | product |  |  |  |  | 0 |  |  |
Revenues |  |  | (759) | $ 1,498 | $ 1,258 | $ 3,789 |  |
Sanofi S.A. | Collaboration And License Agreement |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues under agreement |  | 20,000 |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | 276,300 |  |  |  |  |  |
Number of milestones included in transaction price | milestone |  |  |  |  | 0 |  |  |
Collaborative arrangement transaction price |  | 98,100 |  |  |  |  |  |
Collaborative arrangement estimated reimbursable service costs |  | 64,600 |  |  |  |  |  |
Deferred revenue |  |  | 2,300 |  | $ 2,300 |  | $ 1,200 |
Cumulative milestone achieved |  |  |  |  | 7,000 |  |  |
Sanofi S.A. | Collaboration And License Agreement | Milestone two |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  | 7,500 |  | 7,500 |  |  | $ 7,500
Milestone revenue reversal |  |  | 400 |  | 300 |  |  |
Sanofi S.A. | Collaboration And License Agreement | Milestone three |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  | 13,500 |  | 13,500 |  |  |
Sanofi S.A. | Collaboration And License Agreement | ST-40 Beta Thalassemia Phase 1 clinical trial milestone |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Milestone payments received | $ 6,000 |  |  |  |  |  |  |
Cumulative milestone achieved |  |  |  |  | 5,600 |  |  |
Milestone revenue reversal |  |  | 300 |  | 200 |  |  |
Sanofi S.A. | Collaboration agreement | Change in collaboration agreement scope |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues |  |  | 2,500 |  | 2,500 |  |  |
Net loss |  |  | $ 2,500 |  | $ 2,500 |  |  |
Earnings per share, diluted (in dollars per share) | $ / shares |  |  |  |  | $ 0.02 | $ 0.02 |  |
Earnings per share, basic (in dollars per share) | $ / shares |  |  | $ 0.02 | $ 0.02 |  |  |  |
Sanofi S.A. | Achievement of specified clinical development And regulatory milestones | Collaboration And License Agreement |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | 115,800 |  |  |  |  |  |
Sanofi S.A. | Achievement of specified sales milestones | Collaboration And License Agreement |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | $ 160,500 |  |  |  |  |  |

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