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MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Pfizer Inc. (Detail) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 40 Months Ended | 50 Months Ended
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Sep. 30, 2020 USD ($) | Dec. 31, 2017 USD ($) | May 31, 2017 USD ($) | Sep. 30, 2021 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2021 USD ($) royaltyFee product | Sep. 30, 2020 USD ($) | Mar. 31, 2021 USD ($) product milestone | Jun. 30, 2021 USD ($) milestone
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 28,563,000 | $ 57,763,000 | $ 82,715,000 | $ 92,392,000 |  |
Pfizer SB-525 |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Agreement termination, term |  |  |  |  |  | 15 years |  |  |
Revenues under agreement |  |  |  |  |  | $ 55,000,000 |  |  |
Collaborative arrangement transaction price |  |  |  |  |  | 134,000,000 |  |  |
Research service fees |  |  |  |  |  | 79,000,000 |  |  |
Revenues |  |  |  | 0 |  | $ 0 |  |  |
Pfizer SB-525 | SB-525 and other products |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Number of milestones achieved | milestone |  |  |  |  |  |  |  |  | 2
Milestone payments received |  |  |  |  |  |  |  |  | $ 55,000,000
Number of products approved | product |  |  |  |  |  | 0 |  |  |
Number of milestones included in transaction price | royaltyFee |  |  |  |  |  | 0 |  |  |
Pfizer SB-525 | Recognition of upfront fee |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Cumulative milestone achieved |  |  |  |  | 200,000 |  | 2,700,000 |  |
Pfizer SB-525 | Milestone achievement |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Cumulative milestone achieved |  |  |  |  | 29,900,000 |  | 31,000,000 |  |
Pfizer Inc. |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Milestone payments received |  | $ 12,000,000 |  |  |  |  |  |  |
Revenues |  |  |  | $ 0 |  | $ 0 |  |  |
Pfizer Inc. | SB-525 and other products |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Revenues under agreement |  |  | $ 70,000,000 |  |  |  |  |  |
Potential amount to be funded for achievement of specified commercialized and sales milestones |  |  | 266,500,000 |  |  |  |  |  |
Pfizer Inc. | SB-525 and other products | Achievement of specified clinical development intellectual property and regulatory milestones |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  | 208,500,000 |  |  |  |  |  |
Pfizer Inc. | SB-525 and other products | Achievement of first commercial sale milestones |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  | 475,000,000 |  |  |  |  |  |
Pfizer Inc. | SB-525 |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  | 300,000,000 |  |  |  |  |  |
Pfizer Inc. | Other products |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  | $ 175,000,000 |  |  |  |  |  |
Pfizer Inc. | Recognition of upfront fee |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | 4,200,000 |  | 8,000,000 |  |
Pfizer Inc. | Milestone achievement |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | $ 5,000,000 |  | $ 5,000,000 |  |
Pfizer Inc. | C9ORF72 |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Agreement termination, term |  |  |  |  |  | 15 years |  |  |
Revenues under agreement | $ 5,000,000 | 5,000,000 |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  |  |  |  |  |  | $ 5,000,000 |
Milestone payments received |  | 12,000,000 |  |  |  |  |  |  |
Number of products approved | product |  |  |  |  |  |  |  | 0 |
Number of milestones included in transaction price | milestone |  |  |  |  |  |  |  | 0 |
Collaborative arrangement transaction price |  | 17,000,000 |  |  |  |  |  |  |
Pfizer Inc. | C9ORF72 | Achievement Of Specified Preclinical Development Clinical Development And First Commercial Sale Milestones |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | 60,000,000 |  |  |  |  |  |  |
Pfizer Inc. | C9ORF72 | Achievement Of Commercial Milestones |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | $ 90,000,000 |  |  |  |  |  |  |

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