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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Operating Activities: |  |
Net loss | $ (140,801) | $ (80,447)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |  |
Depreciation and amortization | 6,675 | 3,999
Amortization of premium (discount) on marketable securities | 2,394 | (1,344)
Amortization and other changes in operating lease right-of-use assets | 6,104 | 5,706
Gain on free shares | (18) | (31)
Stock-based compensation | 24,880 | 19,066
(Gain) loss on disposal of property and equipment | (30) | 197
Net changes in operating assets and liabilities: |  |
Interest receivable | 415 | (140)
Accounts receivable | (2,743) | (2,578)
Prepaid expenses and other assets | (6,467) | (9,098)
Accounts payable and other accrued liabilities | (4,699) | 1,336
Accrued compensation and employee benefits | (1,932) | 4,186
Deferred revenues | (62,292) | 235,551
Long-term portion of lease liabilities | (3,227) | (2,760)
Other non-current liabilities | 1,204 | 527
Net cash (used in) provided by operating activities | (180,537) | 174,170
Investing Activities: |  |
Purchases of marketable securities | (300,387) | (335,002)
Maturities of marketable securities | 509,620 | 205,039
Sales of marketable securities | 6,870 | 0
Purchases of property and equipment | (20,420) | (10,703)
Purchase of additional shares of Sangamo France | (119) | (503)
Net cash provided by (used in) investing activities | 195,564 | (141,169)
Financing Activities: |  |
Taxes paid related to net share settlement of equity awards | (2,988) | (573)
Proceeds from exercise of stock options and restricted stock units | 4,582 | 3,041
Net cash provided by financing activities | 30,746 | 146,181
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (148) | (217)
Net increase in cash, cash equivalents, and restricted cash | 45,625 | 178,965
Cash, cash equivalents, and restricted cash, beginning of period | 132,829 | 81,928
Cash, cash equivalents, and restricted cash, end of period | 178,454 | 260,893
Supplemental cash flow disclosures: |  |
Property and equipment included in unpaid liabilities | 650 | 899
Right-of-use assets obtained in exchange for lease obligations | 1,349 | 0
Buy-out of non-controlling interest | 943 | 0
At the Market Offering |  |
Financing Activities: |  |
Proceeds from issuance of common stock | 27,099 | 0
Biogen Collaboration Agreement |  |
Financing Activities: |  |
Proceeds from issuance of common stock | 0 | 142,526
Employee Stock |  |
Financing Activities: |  |
Proceeds from issuance of common stock | $ 2,053 | $ 1,187

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