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ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIIES - Additional Information (Detail) | 12 Months Ended
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Dec. 31, 2021 USD ($) segment $ / shares shares | Dec. 31, 2020 USD ($) $ / shares shares | Dec. 31, 2019 USD ($) $ / shares shares
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Revenues | $ 110,701,000 | $ 118,192,000 | $ 102,428,000
Net loss | $ (178,297,000) | $ (121,122,000) | $ (95,419,000)
Earnings per share, basic (in dollars per share) | $ / shares | $ (1.23) | $ (0.90) | $ (0.85)
Goodwill and intangible asset impairment | $ 0 |  |
Impairment of long-lived assets held-for-use | 0 |  |
Letter of credit | $ 1,500,000 |  |
Stock options and RSUs outstanding (in shares) | shares | 15,159,908 | 14,237,871 | 10,750,550
Number of operating segments | segment | 1 |  |
Pfizer SB-525 |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Revenues | $ 0 |  |
Pfizer SB-525 | Change in collaboration agreement scope | Collaborative arrangement |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Revenues | 1,600,000 | $ 8,900,000 | $ 5,700,000
Net loss | $ 1,600,000 | $ 8,900,000 | $ 5,700,000
Earnings per share, basic (in dollars per share) | $ / shares | $ 0.01 | $ 0.06 | $ 0.05
Minimum |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 3 years |  |
Maximum |  |  |
Organization and Summary of Significant Accounting Policies [Line Items] |  |  |
Estimated useful lives of related assets | 5 years |  |

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