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MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Sanofi S.A. (Details) | 1 Months Ended | 12 Months Ended | 29 Months Ended |
--- | --- | --- | --- | ---
Jan. 31, 2014 USD ($) program | Dec. 31, 2021 USD ($) product milestone $ / shares | Dec. 31, 2020 USD ($) $ / shares | Dec. 31, 2019 USD ($) $ / shares | Dec. 31, 2021 USD ($) | Aug. 31, 2019 USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Accounts receivable |  | $ 6,013,000 | $ 5,224,000 |  | $ 6,013,000 |
Revenues |  | 110,701,000 | 118,192,000 | $ 102,428,000 |  |
Net loss |  | $ (178,297,000) | $ (121,122,000) | $ (95,419,000) |  |
Earnings per share, basic (in dollars per share) | $ / shares |  | $ (1.23) | $ (0.90) | $ (0.85) |  |
Sanofi S.A. |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Number of research programs | program | 2 |  |  |  |  |
Revenues under agreement | $ 20,000,000 |  |  |  |  |
Number of products approved | product |  | 0 |  |  |  |
Revenues |  | $ 3,114,000 | $ 5,322,000 | $ 22,680,000 |  |
Collaborative arrangement, increase (decrease) in revenue |  |  | 2,200,000 |  |  |
Collaborative arrangement, increase (decrease) in net income (loss) |  |  | $ 2,200,000 |  |  |
Collaborative arrangement, net income (loss) per share | $ / shares |  |  | $ 0.02 |  |  |
Sanofi S.A. | Collaboration and license agreement |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Revenues under agreement |  | $ 20,000,000 |  |  |  |
Number of milestones included in transaction price | milestone |  | 0 |  |  |  |
Collaborative arrangement transaction price |  | $ 96,300,000 |  |  |  |
Collaborative arrangement estimated reimbursable service costs | 62,800,000 |  |  |  |  |
Accounts receivable |  | 600,000 | $ 1,000,000 |  | 600,000 |
Deferred revenue |  | 1,100,000 | 1,200,000 |  | 1,100,000 |
Recognition of milestone |  | 100,000 |  |  |  |
Sanofi S.A. | Collaboration and license agreement | Maximum |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Development and sales-based milestone payments to be received | 276,300,000 |  |  |  |  |
Sanofi S.A. | Collaboration and license agreement | Achievement of specified clinical development and regulatory milestones | Maximum |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Development and sales-based milestone payments to be received | 115,800,000 |  |  |  |  |
Sanofi S.A. | Collaboration and license agreement | Achievement of specified sales milestones | Maximum |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Development and sales-based milestone payments to be received | $ 160,500,000 |  |  |  |  |
Sanofi S.A. | Collaboration and license agreement | Milestone One |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Milestone payments received |  | 6,000,000 |  |  |  |
Milestone revenue receivable |  |  |  |  |  | $ 6,000,000
Recognition of milestone |  |  |  |  | 5,900,000 |
Sanofi S.A. | Collaboration and license agreement | Milestone Two |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Milestone revenue receivable |  | 7,500,000 |  | 7,500,000 | 7,500,000 |
Recognition of milestone |  | 7,300,000 |  |  |  |
Sanofi S.A. | Collaboration and license agreement | Milestone Three |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Milestone revenue receivable |  | 13,500,000 |  |  | $ 13,500,000 |
Recognition of milestone |  | 100,000 |  |  |  |
Pfizer SB-525 |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Revenues under agreement |  | 55,000,000 |  |  |  |
Collaborative arrangement transaction price |  | 134,000,000 |  |  |  |
Revenues |  | 0 |  |  |  |
Pfizer SB-525 | Collaborative arrangement | Change in collaboration agreement scope |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |
Revenues |  | 1,600,000 | 8,900,000 | 5,700,000 |  |
Net loss |  | $ 1,600,000 | $ 8,900,000 | $ 5,700,000 |  |
Earnings per share, basic (in dollars per share) | $ / shares |  | $ 0.01 | $ 0.06 | $ 0.05 |  |

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