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OTHER BALANCE SHEET DETAILS | 12 Months Ended
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Dec. 31, 2021
Balance Sheet Related Disclosures [Abstract] |
OTHER BALANCE SHEET DETAILS | OTHER BALANCE SHEET DETAILS Property and Equipment, Net Property and equipment, net consist of the following (in thousands):
| December 31,
| 2021 |  | 2020
Laboratory equipment | $ | 31,988 |  |  | $ | 24,737 |
Leasehold improvements | 21,970 |  |  | 15,953 |
Furniture and fixtures | 9,080 |  |  | 4,870 |
Manufacturing equipment | 8,781 |  |  | 1,089 |
Construction in progress | 4,729 |  |  | 12,091 |
| 76,548 |  |  | 58,740 |
Less: accumulated depreciation and amortization | (25,025) |  |  | (17,416) |
Property and equipment, net | $ | 51,523 |  |  | $ | 41,324 |
Depreciation and amortization expense was $9.4 million in 2021, $5.7 million in 2020 and $3.9 million in 2019. Intangible Assets The changes in intangible assets were as follows (in thousands):
| December 31,
| 2021 |  | 2020
Balance at beginning of year | $ | 58,128 |  |  | $ | 53,156 |
Foreign currency translation adjustment | (4,368) |  |  | 4,972 |
Balance at end of year | $ | 53,760 |  |  | $ | 58,128 |
Goodwill The changes in goodwill were as follows (in thousands):
| December 31,
| 2021 |  | 2020
Balance at beginning of year | $ | 42,798 |  |  | $ | 39,273 |
Foreign currency translation adjustment | (3,096) |  |  | 3,525 |
Balance at end of year | $ | 39,702 |  |  | $ | 42,798 |
Other Accrued Liabilities Other accrued liabilities consist of the following (in thousands):
| December 31,
| 2021 |  | 2020
Accrued research and development expenses | $ | 4,878 |  |  | $ | 4,257 |
Operating lease liabilities – current | 4,026 |  |  | 3,690 |
Accrued professional fees | 869 |  |  | 1,532 |
Customer advance | — |  |  | 5,000 |
Other | 1,804 |  |  | 4,133 |
Total other accrued liabilities | $ | 11,577 |  |  | $ | 18,612 |

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- Definition The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -URI http://asc.fasb.org/topic&trid=2122208 + Details
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