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MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Pfizer Inc. (Detail) | 1 Months Ended | 3 Months Ended | 12 Months Ended | 52 Months Ended | 59 Months Ended
--- | --- | --- | --- | --- | ---
Sep. 30, 2020 USD ($) | Dec. 31, 2017 USD ($) | May 31, 2017 USD ($) | Mar. 31, 2022 USD ($) | Mar. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Mar. 31, 2022 USD ($) milestone royalty_fee | Mar. 31, 2022 USD ($) milestone product
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues |  |  |  | $ 28,231,000 | $ 26,280,000 |  |  |
Pfizer Inc. |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Agreement termination, term |  |  | 15 years |  |  |  |  |
Pfizer Inc. | S B Five Two Five And Other Products |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues under agreement |  |  | $ 70,000,000 |  |  |  |  |
Potential amount to be funded for achievement of specified commercialized and sales milestones |  |  | 266,500,000 |  |  |  |  |
Milestone revenue receivable |  |  | 300,000,000 |  |  |  |  |
Pfizer Inc. | S B Five Two Five And Other Products | Achievement of specified clinical development intellectual property and regulatory milestones |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  | 208,500,000 |  |  |  |  |
Pfizer Inc. | S B Five Two Five And Other Products | Achievement of first commercial sale milestones |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  |  | 475,000,000 |  |  |  |  |
Pfizer Inc. | Other products |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Milestone revenue receivable |  |  | 175,000,000 |  |  |  |  |
Pfizer Inc. | C9ORF72 |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues under agreement |  | $ 5,000,000 |  |  |  | $ 5,000,000 |  |
Development and sales-based milestone payments to be received | $ 5,000,000 |  |  |  |  |  |  |
Collaborative arrangement transaction price |  | $ 17,000,000 |  |  |  |  |  |
Pfizer SB-525 |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues under agreement |  |  |  |  |  |  |  | $ 55,000,000
Collaborative arrangement transaction price |  |  | 134,000,000 |  |  |  |  |
Research service fees |  |  | $ 79,000,000 |  |  |  |  |
Revenues |  |  |  | 0 | 0 |  |  |
Pfizer SB-525 | S B Five Two Five And Other Products |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Collaborative arrangement, number of milestones achieved | milestone |  |  |  |  |  |  |  | 2
Milestone payments received |  |  |  |  |  |  |  | $ 55,000,000
Number of products approved | product |  |  |  |  |  |  |  | 0
Number of milestones included in transaction price | royalty_fee |  |  |  |  |  |  | 0 |
Pfizer C9ORF72 |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Agreement termination, term |  | 15 years |  |  |  |  |  |
Milestone payments received |  | $ 12,000,000 |  |  |  |  | $ 5,000,000 |
Number of products approved | milestone |  |  |  |  |  |  | 0 |
Number of milestones included in transaction price | milestone |  |  |  |  |  |  | 0 |
Pfizer C9ORF72 | C9ORF72 |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Revenues under agreement |  | 12,000,000 |  |  |  |  |  |
Revenues |  |  |  | $ 0 | $ 0 |  |  |
Pfizer C9ORF72 | C9ORF72 | Achievement Of Specified Preclinical Development Clinical Development And First Commercial Sale Milestones | Maximum |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | 60,000,000 |  |  |  |  |  |
Pfizer C9ORF72 | C9ORF72 | Achievement Of Commercial Milestones | Maximum |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |
Development and sales-based milestone payments to be received |  | $ 90,000,000 |  |  |  |  |  |

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