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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Operating Activities: |  |
Net loss | $ (87,150) | $ (93,113)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 5,716 | 4,120
Amortization of premium on marketable securities | 207 | 1,733
Amortization and other changes in operating lease right-of-use assets | 4,225 | 4,067
Gain on free shares | 0 | (18)
Stock-based compensation | 15,609 | 17,007
Net changes in operating assets and liabilities: |  |
Interest receivable | 60 | 228
Accounts receivable | 11 | (1,658)
Prepaid expenses and other assets | (4,992) | (4,441)
Accounts payable and other accrued liabilities | 5,796 | (3,204)
Accrued compensation and employee benefits | (6,618) | (3,253)
Deferred revenues | (43,772) | (41,481)
Lease liabilities | (2,121) | (2,102)
Other non-current liabilities | 69 | 998
Net cash used in operating activities | (112,960) | (121,117)
Investing Activities: |  |
Purchases of marketable securities | (129,928) | (180,049)
Maturities of marketable securities | 168,346 | 323,099
Sales of marketable securities | 0 | 6,870
Purchases of property and equipment | (8,284) | (15,213)
Purchase of additional Sangamo France shares | 0 | (119)
Net cash provided by investing activities | 30,134 | 134,588
Financing Activities: |  |
Taxes paid related to net share settlement of equity awards | (1,827) | (2,725)
Proceeds from exercise of stock options | 90 | 3,702
Net cash provided by financing activities | 21,307 | 25,254
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | 352 | (176)
Net (decrease) increase in cash, cash equivalents, and restricted cash | (61,167) | 38,549
Cash, cash equivalents, and restricted cash, beginning of period | 180,372 | 132,829
Cash, cash equivalents, and restricted cash, end of period | 119,205 | 171,378
Supplemental cash flow disclosures: |  |
Property and equipment included in unpaid liabilities | 2,232 | 2,267
Right-of-use assets obtained in exchange for lease obligations | 0 | 1,364
Buy-out of non-controlling interest | 0 | 943
At the Market Offering |  |
Financing Activities: |  |
Proceeds from at-the market offering/ issuance of common stock | 21,929 | 22,223
Employee Stock |  |
Financing Activities: |  |
Proceeds from at-the market offering/ issuance of common stock | $ 1,115 | $ 2,054

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