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v3.22.2.2

ORGANIZATION, BASIS OF PRESENTATION, AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 9 Months Ended | 102 Months Ended
--- | --- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Jun. 28, 2022
Change in Accounting Estimate [Line Items] |  |  |  |  |
Decreased revenue | $ (26,460) | $ (28,563) | $ (84,069) | $ (82,715) |
Increased net loss | $ 53,155 | $ 47,688 | $ 140,305 | $ 140,801 |
Increased earnings per share, basic (in dollars per share) | $ (0.34) | $ (0.33) | $ (0.93) | $ (0.98) |
Increased earnings per share, diluted (in dollars per share) | $ (0.34) | $ (0.33) | $ (0.93) | $ (0.98) |
Letter of credit established as a deposit | $ 1,500 |  | $ 1,500 |  |
Sanofi S.A. |  |  |  |  |
Change in Accounting Estimate [Line Items] |  |  |  |  |
Decreased revenue | $ 0 | $ 759 | $ (3,260) | $ (1,258) | $ (13,500)
Sanofi S.A. | Change In Collaboration Agreement Scope | Collaboration agreement |  |  |  |  |
Change in Accounting Estimate [Line Items] |  |  |  |  |
Decreased revenue |  | 2,500 |  | 2,500 |
Increased net loss |  | $ 2,500 |  | $ 2,500 |
Increased earnings per share, basic (in dollars per share) |  | $ 0.02 |  | $ 0.02 |
Increased earnings per share, diluted (in dollars per share) |  | $ 0.02 |  | $ 0.02 |

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