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OTHER BALANCE SHEET DETAILS | 12 Months Ended
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Dec. 31, 2023
Balance Sheet Related Disclosures [Abstract] |
OTHER BALANCE SHEET DETAILS | OTHER BALANCE SHEET DETAILS Property and Equipment, Net Property and equipment, net consist of the following (in thousands):
| December 31,
| 2023 |  | 2022
Laboratory equipment | $ | 34,630 |  |  | $ | 39,080 |
Leasehold improvements | 29,809 |  |  | 30,572 |
Furniture and fixtures | 4,610 |  |  | 5,731 |
Manufacturing equipment | 7,784 |  |  | 9,908 |
Construction in progress | 1,087 |  |  | 14,770 |
| 77,920 |  |  | 100,061 |
Less: accumulated depreciation and amortization | (51,046) |  |  | (36,530) |
Property and equipment, net | $ | 26,874 |  |  | $ | 63,531 |
Depreciation and amortization expense was $15.1 million in 2023, $12.1 million in 2022 and $9.4 million in 2021. During the year ended December 31, 2023, the Company recorded impairment losses of $23.1 million for its leasehold improvements, $8.0 million for its laboratory equipment, $2.3 million for its manufacturing equipment, $1.6 million for its furniture and fixtures, and $1.6 million for its construction in progress. The Company did not record any impairment losses in 2022 and 2021. Intangible Assets The changes in intangible assets were as follows (in thousands):
| December 31,
| 2023 |  | 2022
Balance at beginning of year | $ | 50,729 |  |  | $ | 53,760 |
Foreign currency translation adjustment | 618 |  |  | (3,031) |
Impairment of indefinite-lived intangible asset | (51,347) |  |  | — |
Balance at end of year | $ | — |  |  | $ | 50,729 |
Goodwill The changes in goodwill were as follows (in thousands):
| December 31,
| 2023 |  | 2022
Balance at beginning of year | $ | 37,552 |  |  | $ | 39,702 |
Foreign currency translation adjustment | 586 |  |  | (2,150) |
Impairment of goodwill | (38,138) |  |  | — |
Balance at end of year | $ | — |  |  | $ | 37,552 |
Other Accrued Liabilities Other accrued liabilities consist of the following (in thousands):
| December 31,
| 2023 |  | 2022
Accrued restructuring expenses | $ | 11,733 |  |  | $ | — |
Operating lease liabilities – current | 4,589 |  |  | 4,122 |
Accrued research and development expenses | 3,763 |  |  | 7,115 |
Accrued professional fees | 1,505 |  |  | 1,704 |
Other | 1,964 |  |  | 3,066 |
Total other accrued liabilities | $ | 23,554 |  |  | $ | 16,007 |

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- Definition The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 210 -Name Accounting Standards Codification -Publisher FASB -URI https://asc.fasb.org//210/tableOfContent + Details
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