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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating Activities: |  |  |
Net loss | $ (257,831,000) | $ (192,278,000) | $ (178,297,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Impairment of goodwill and indefinite-lived intangible assets | 89,485,000 | 0 | 0
Impairment of long-lived assets | 65,528,000 | 0 | 0
Depreciation and amortization | 15,065,000 | 12,108,000 | 9,439,000
(Accretion of discount) amortization of premium on marketable securities | (2,329,000) | (1,242,000) | 2,844,000
Amortization in operating lease right-of-use assets | 7,127,000 | 8,454,000 | 8,199,000
Deferred income tax benefit | (6,335,000) | 0 | 0
Stock-based compensation | 27,363,000 | 31,650,000 | 32,956,000
Other | 1,119,000 | 0 | (70,000)
Adjustment of CIRM award liability related to termination of the grant | 0 | 0 | (6,427,000)
Net changes in operating assets and liabilities: |  |  |
Interest receivable | 392,000 | (445,000) | 686,000
Accounts receivable | 2,755,000 | 2,335,000 | (789,000)
Prepaid expenses and other assets | 6,133,000 | (4,909,000) | (7,175,000)
Accounts payable and other accrued liabilities | 5,589,000 | 13,348,000 | (7,664,000)
Accrued compensation and employee benefits | (12,690,000) | 941,000 | 373,000
Deferred revenues | (161,156,000) | (91,331,000) | (84,202,000)
Lease liabilities | (5,037,000) | (2,249,000) | (4,340,000)
Other non-current liabilities | (20,000) | (9,000) | 1,216,000
Net cash used in by operating activities | (224,842,000) | (223,627,000) | (233,251,000)
Investing Activities: |  |  |
Purchases of marketable securities | (59,551,000) | (277,391,000) | (338,159,000)
Maturities of marketable securities | 214,500,000 | 354,587,000 | 602,885,000
Sales of marketable securities | 19,737,000 | 2,260,000 | 6,870,000
Purchases of property and equipment | (21,155,000) | (20,171,000) | (23,278,000)
Purchase of additional Sangamo France shares | 0 | 0 | (119,000)
Net cash provided by investing activities | 153,531,000 | 59,285,000 | 248,199,000
Financing Activities: |  |  |
Taxes paid related to net share settlement of equity awards | (1,453,000) | (2,104,000) | (3,258,000)
Proceeds from exercise of stock options | 0 | 124,000 | 5,648,000
Net cash provided by financing activities | 14,588,000 | 84,660,000 | 32,858,000
Effect of exchange rate changes on cash and cash equivalents, and restricted cash | 1,483,000 | 1,254,000 | (263,000)
Net (decrease) increase in cash, cash equivalents, and restricted cash | (55,240,000) | (78,428,000) | 47,543,000
Cash, cash equivalents, and restricted cash, beginning of period | 101,944,000 | 180,372,000 | 132,829,000
Cash, cash equivalents, and restricted cash, end of period | 46,704,000 | 101,944,000 | 180,372,000
Supplemental cash flow disclosures: |  |  |
Property and equipment included in unpaid liabilities | 447,000 | 6,539,000 | 1,535,000
Tenant improvement allowance included in contra-lease liability | 0 | 243,000 | 0
Buy-out of non-controlling interest | 0 | 0 | 943,000
Right-of-use assets obtained in exchange for lease obligations | 0 | 0 | 10,418,000
At-The-Market Offering |  |  |
Financing Activities: |  |  |
Proceeds from issuance of common stock | 15,106,000 | 84,869,000 | 27,099,000
Employee Stock |  |  |
Financing Activities: |  |  |
Proceeds from issuance of common stock | $ 935,000 | $ 1,771,000 | $ 3,369,000

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