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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating Activities:      
Net loss $ (257,831,000) $ (192,278,000) $ (178,297,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Impairment of goodwill and indefinite-lived intangible assets 89,485,000 0 0
Impairment of long-lived assets 65,528,000 0 0
Depreciation and amortization 15,065,000 12,108,000 9,439,000
(Accretion of discount) amortization of premium on marketable securities (2,329,000) (1,242,000) 2,844,000
Amortization in operating lease right-of-use assets 7,127,000 8,454,000 8,199,000
Deferred income tax benefit (6,335,000) 0 0
Stock-based compensation 27,363,000 31,650,000 32,956,000
Other 1,119,000 0 (70,000)
Adjustment of CIRM award liability related to termination of the grant 0 0 (6,427,000)
Net changes in operating assets and liabilities:      
Interest receivable 392,000 (445,000) 686,000
Accounts receivable 2,755,000 2,335,000 (789,000)
Prepaid expenses and other assets 6,133,000 (4,909,000) (7,175,000)
Accounts payable and other accrued liabilities 5,589,000 13,348,000 (7,664,000)
Accrued compensation and employee benefits (12,690,000) 941,000 373,000
Deferred revenues (161,156,000) (91,331,000) (84,202,000)
Lease liabilities (5,037,000) (2,249,000) (4,340,000)
Other non-current liabilities (20,000) (9,000) 1,216,000
Net cash used in by operating activities (224,842,000) (223,627,000) (233,251,000)
Investing Activities:      
Purchases of marketable securities (59,551,000) (277,391,000) (338,159,000)
Maturities of marketable securities 214,500,000 354,587,000 602,885,000
Sales of marketable securities 19,737,000 2,260,000 6,870,000
Purchases of property and equipment (21,155,000) (20,171,000) (23,278,000)
Purchase of additional Sangamo France shares 0 0 (119,000)
Net cash provided by investing activities 153,531,000 59,285,000 248,199,000
Financing Activities:      
Taxes paid related to net share settlement of equity awards (1,453,000) (2,104,000) (3,258,000)
Proceeds from exercise of stock options 0 124,000 5,648,000
Net cash provided by financing activities 14,588,000 84,660,000 32,858,000
Effect of exchange rate changes on cash and cash equivalents, and restricted cash 1,483,000 1,254,000 (263,000)
Net (decrease) increase in cash, cash equivalents, and restricted cash (55,240,000) (78,428,000) 47,543,000
Cash, cash equivalents, and restricted cash, beginning of period 101,944,000 180,372,000 132,829,000
Cash, cash equivalents, and restricted cash, end of period 46,704,000 101,944,000 180,372,000
Supplemental cash flow disclosures:      
Property and equipment included in unpaid liabilities 447,000 6,539,000 1,535,000
Tenant improvement allowance included in contra-lease liability 0 243,000 0
Buy-out of non-controlling interest 0 0 943,000
Right-of-use assets obtained in exchange for lease obligations 0 0 10,418,000
At-The-Market Offering      
Financing Activities:      
Proceeds from issuance of common stock 15,106,000 84,869,000 27,099,000
Employee Stock      
Financing Activities:      
Proceeds from issuance of common stock $ 935,000 $ 1,771,000 $ 3,369,000