<SEC-DOCUMENT>0001140361-24-046239.txt : 20241112
<SEC-HEADER>0001140361-24-046239.hdr.sgml : 20241112
<ACCEPTANCE-DATETIME>20241112172520
ACCESSION NUMBER:		0001140361-24-046239
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20241112
DATE AS OF CHANGE:		20241112
EFFECTIVENESS DATE:		20241112

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SANGAMO THERAPEUTICS, INC
		CENTRAL INDEX KEY:			0001001233
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				680359556
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-283180
		FILM NUMBER:		241450023

	BUSINESS ADDRESS:	
		STREET 1:		501 CANAL BLVD.
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94084
		BUSINESS PHONE:		5109706000

	MAIL ADDRESS:	
		STREET 1:		501 CANAL BLVD.
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94084

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SANGAMO BIOSCIENCES INC
		DATE OF NAME CHANGE:	20000208
</SEC-HEADER>
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    <div>
      <div style="text-align: center; font-weight: bold;">As filed with the Securities and Exchange Commission on November 12, 2024</div>
      <div><br>
      </div>
      <div style="text-align: right; font-weight: bold;">Registration No. 333-</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Washington, D.C. 20549</div>
      <div><br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 18pt; font-weight: bold;">REGISTRATION STATEMENT</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">UNDER</div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">THE SECURITIES ACT OF 1933</div>
      <div><br>
      </div>
      <div style="text-align: center; font-family: 'Times New Roman',Times,serif; font-size: 24pt; font-weight: bold;">SANGAMO THERAPEUTICS, INC.</div>
      <div style="text-align: center; font-weight: bold;">(Exact name of registrant as specified in its charter)</div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zf6f613440f4546079adddf23fd907f86" border="0" cellpadding="0" cellspacing="0">

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            <td style="width: 49%; vertical-align: middle;">&#160;</td>
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            <td style="width: 49%; vertical-align: middle;">&#160;</td>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">Delaware</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">68-0359556</div>
            </td>
          </tr>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(State or other jurisdiction of</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">&#160;incorporation or organization)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(I.R.S. Employer</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">&#160;Identification No.)</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: middle;">&#160;</td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: middle;">&#160;</td>
          </tr>
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            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">501 Canal Blvd.</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">&#160;Richmond, California</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: bottom;">
              <div style="text-align: center; color: #000000; font-weight: bold;">94084</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(Address of Principal Executive Offices)</div>
            </td>
            <td style="width: 2%; vertical-align: bottom;">&#160;</td>
            <td style="width: 49%; vertical-align: top;">
              <div style="text-align: center; color: #000000; font-weight: bold;">(Zip Code)</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; font-weight: bold;">Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan</div>
      <div style="text-align: center; font-weight: bold;">(Full title of the plan)</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">Alexander D. Macrae</div>
      <div style="text-align: center; font-weight: bold;">President and Chief Executive Officer</div>
      <div style="text-align: center; font-weight: bold;">Sangamo Therapeutics, Inc.</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">501 Canal Blvd.</div>
      <div style="text-align: center; font-weight: bold;">Richmond, California 94084</div>
      <div style="text-align: center; font-weight: bold;">(510) 970-6000</div>
      <div style="text-align: center; font-weight: bold;">(Name and address of agent for service) (telephone number, including area code, of agent for service)</div>
      <div><br>
      </div>
      <div style="text-align: center; font-style: italic; font-weight: bold;">Copies to:</div>
      <div><br>
      </div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z5d0e3534f23e496599bc8bfcc3b81ea5" border="0" cellpadding="0" cellspacing="0">

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            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Scott Willoughby</div>
              <div style="text-align: center; font-weight: bold;">&#160;Senior Vice President and General Counsel</div>
              <div style="text-align: center; text-indent: 6.1pt; color: #000000; font-weight: bold;">&#160;Sangamo Therapeutics, Inc.</div>
              <div>
                <div style="text-align: center; font-weight: bold;">&#160;501 Canal Blvd.</div>
              </div>
              <div style="text-align: center; text-indent: 6.1pt; font-weight: bold;">&#160;Richmond, California 94084</div>
              <div>
                <div style="text-align: center; color: #000000; font-weight: bold;">&#160;(510) 970-6000</div>
              </div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; font-weight: bold;">Chadwick L. Mills</div>
              <div style="text-align: center; font-weight: bold;">&#160;Courtney M.W. Tygesson</div>
              <div style="text-align: center; font-weight: bold;">&#160;Cooley LLP</div>
              <div style="text-align: center; font-weight: bold;">&#160;3 Embarcadero Center, 20th Floor</div>
              <div style="text-align: center; font-weight: bold;">&#160;San Francisco, CA&#160; 94111</div>
              <div style="text-align: center; font-weight: bold;">&#160;(415) 693-2000</div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated
        filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div>
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          <tr>
            <td style="width: 15.83%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: middle;">&#160;</td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 15.83%; vertical-align: bottom;">
              <div style="color: #000000;">Large accelerated filer</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: bottom;">
              <div style="color: #000000;">Accelerated filer</div>
            </td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 15.83%; vertical-align: bottom;">
              <div style="color: #000000;">Non-accelerated filer</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
            </td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: bottom;">
              <div style="color: #000000;">Smaller reporting company</div>
            </td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 15.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 59.86%; vertical-align: bottom;">&#160;</td>
            <td style="width: 0.83%; vertical-align: bottom;">&#160;</td>
            <td style="width: 19%; vertical-align: bottom;">
              <div style="color: #000000;">Emerging growth company</div>
            </td>
            <td style="width: 0.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 1.96%; vertical-align: bottom;">
              <div style="color: #000000; font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</div>
            </td>
          </tr>

      </table>
      <div>If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the
        Securities Act. &#9744;</div>
      <div>
        <hr style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;" align="center"></div>
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      <div style="text-align: center; font-weight: bold;">EXPLANATORY NOTE</div>
      <div><br>
      </div>
      <div>This Registration Statement on Form S-8 is being filed by Sangamo Therapeutics, Inc. (the &#8220;Registrant&#8221;) with the Securities and Exchange Commission (the &#8220;Commission&#8221;) for the purpose of registering an additional 11,000,000 shares of the
        Registrant&#8217;s common stock, par value $0.01 per share (the &#8220;Common Stock&#8221;), to be issued pursuant to the Registrant&#8217;s Amended and Restated 2018 Equity Incentive Plan (the &#8220;2018 Plan&#8221;).&#160; The Registrant previously registered (i) 19,131,725 shares of
        Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312518189435/d603403ds8.htm">Form S-8</a> (File No. 333-225552)
        filed with the Commission on June 11, 2018 (the &#8220;2018 Form S-8&#8221;), (ii) 9,900,000 shares of Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312520210798/d24713ds8.htm">Form S-8</a> (File No. 333-241033) filed with the Commission on August 5, 2020 (the &#8220;2020 Form S-8&#8221;), (iii) 7,900,000 shares of Common Stock that are or may
        become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312523045598/d469019ds8.htm">Form S-8</a> (File No. 333-269925) filed with the Commission on
        February 23, 2023 (the &#8220;2023 Form S-8&#8221;), and (iv) 10,000,000 shares of Common Stock that are or may become issuable under the 2018 Plan pursuant to the Registrant&#8217;s registration statement on <a href="https://www.sec.gov/Archives/edgar/data/1001233/000119312523206301/d499172ds8.htm">Form S-8</a> (File No. 333-273805) filed with the Commission on August 8, 2023 (together with the 2018 Form S-8, the 2020 Form S-8, and the 2023 Form S-8,
        the &#8220;Prior Registration Statements&#8221;). This<font style="color: #000000;"> Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General
          Instruction E of Form S-8. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated by reference herein.</font></div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">PART II</div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
      <div><br>
      </div>
      <div><font style="font-weight: bold;">Item 3.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Incorporation of Documents by Reference</font></div>
      <div><br>
      </div>
      <div>The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement:</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z15e5a372e36347edb70f98689f1aeb0c" cellpadding="0" cellspacing="0">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the Registrant&#8217;s annual report on Form 10-K for the year ended December 31, 2023, which was filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024010788/sgmo-20231231.htm">March 13, 2024</a><font style="color: #000000;">;</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z069850e938ba45278e258019f5cd962d" cellpadding="0" cellspacing="0">

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            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the information specifically incorporated by reference into the Registrant&#8217;s annual report on Form 10-K for the year ended December 31, 2023 from the Registrant&#8217;s definitive proxy statement on </font>Schedule








                14A<font style="color: #000000;">, which was filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024016932/sgmo-20240419.htm">April 19, 2024</a><font style="color: #000000;">;</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8d9ac4cf5f87419eaec5c357b1c28917" cellpadding="0" cellspacing="0">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the Registrant&#8217;s quarterly reports on </font>Form 10-Q<font style="color: #000000;"> for the quarters ended March 31, 2024, June 30, 2024 and September 30, 2024, which were filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024022194/sgmo-20240331.htm">May 9, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024035165/sgmo-20240630.htm">August 6,
                  2024</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1001233/000162828024047102/sgmo-20240930.htm">November 12, 2024</a>, respectively<font style="color: #000000;">;</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf61f6b632e7f4314881d3dff1b83e1f8" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the Registrant&#8217;s current reports on Form 8-K, which were filed with the Commission on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024001784/sgmo-20240119.htm">January
                  19, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024003506/sgmo-20240205.htm">February 6, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000119312524076613/d816036d8k.htm">March 25, 2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024019337/sgmo-20240424.htm">April 30,
                  2024</a>, <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024026903/sgmo-20240604.htm">June 5, 2024</a> and <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001001233/000162828024032815/sgmo-20240724.htm">July 24, 2024</a><font style="color: #000000;">; and</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd5350c089f9b4ec8a2e419663bba1109" cellpadding="0" cellspacing="0">

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            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 18pt; vertical-align: top;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div><font style="color: #000000;">the description of the Common Stock contained in the Registrant&#8217;s registration statement on </font><a href="https://www.sec.gov/Archives/edgar/data/1001233/000095014900000735/0000950149-00-000735.txt">Form
                  8-A</a><font style="color: #000000;">, which was filed with the Commission on March 31, 2000, including all amendments and reports filed for the purpose of updating such description, including </font><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828024010788/sgmo-20231231xex41.htm">Exhibit 4.1</a> <font style="color: #000000;">of the Registrant&#8217;s annual report on </font><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/1001233/000162828024010788/sgmo-20231231.htm">Form 10-K</a><font style="color: #000000;"> for the year ended December 31, 2023.</font></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div>All reports and other documents filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, other than Current Reports furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits
        furnished on such form that relate to such items, after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
        securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part of this Registration Statement from the date of filing such reports and documents. Any statement contained in a document incorporated or
        deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to
        be incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.</div>
      <div><br>
      </div>
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          <tr>
            <td style="width: 72pt; vertical-align: top; font-weight: bold;">Item 8.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-weight: bold;">Exhibits</div>
            </td>
          </tr>

      </table>
      <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z902656b5377a420d99980218b11ec159" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 8.42%; vertical-align: middle;">&#160;</td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: bottom; border-bottom: 2px solid black;" nowrap="nowrap">
              <div style="text-align: center; color: #000000; font-weight: bold;">Exhibit</div>
              <div style="text-align: center; color: #000000; font-weight: bold;">Number</div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: bottom; border-bottom: 2px solid black;" nowrap="nowrap">
              <div style="color: #000000; font-weight: bold;">Description</div>
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          <tr>
            <td style="width: 8.42%; vertical-align: middle;">&#160;</td>
            <td colspan="2" style="width: 91.58%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828023020692/sgmo-20230602xex33.htm">4.1</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.3 to the Registrant&#8217;s Current Report on Form 8-K filed June 2, 2023).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828024026903/sgmo-20240605xex31.htm">4.2</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Certificate of Amendment of the Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company&#8217;s Current Report on Form 8-K filed June 5, 2024).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828022032209/sgmo-20221219xxex31fifth.htm">4.3</a></div>
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            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Fifth Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 to the Registrant&#8217;s Current Report on Form 8-K filed December 19, 2022).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="ny20037443x2_ex5-1.htm">5.1</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Opinion of Cooley LLP.</div>
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          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="ny20037443x2_ex23-1.htm">23.1</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Consent of Independent Registered Public Accounting Firm.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="ny20037443x2_ex5-1.htm">23.2</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Consent of Cooley LLP is contained in Exhibit 5.1 to this Registration Statement.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="#POWEROFATTORNEY">24.1</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Power of Attorney is contained on the signature page hereto.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1001233/000162828024026903/ex-101amendedandrestated.htm">99.1</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant&#8217;s Current Report on Form 8-K filed June 5, 2024).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 8.42%; vertical-align: top;" nowrap="nowrap">
              <div style="text-align: center; color: #000000;"><a href="ny20037443x2_ex107.htm">107</a></div>
            </td>
            <td style="width: 4.72%; vertical-align: bottom;">&#160;</td>
            <td style="width: 86.86%; vertical-align: top;">
              <div>Filing fee table.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div><br>
      </div>
      <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
      <div><br>
      </div>
      <div>Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration
        statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Richmond, State of California, on November 12, 2024.</div>
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            <td style="width: 9.48%; vertical-align: middle;">&#160;</td>
            <td style="width: 1%; vertical-align: bottom;">&#160;</td>
            <td style="width: 89.53%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td colspan="3" style="width: 100%; vertical-align: top;">
              <div style="color: #000000; font-weight: bold;">SANGAMO THERAPEUTICS, INC.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.48%; vertical-align: middle;">&#160;</td>
            <td colspan="2" style="width: 90.52%; vertical-align: middle;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 9.48%; vertical-align: top;">
              <div style="color: #000000;">By:</div>
            </td>
            <td style="width: 1%; vertical-align: bottom; border-bottom: #000000 2px solid;">&#160;</td>
            <td style="width: 89.53%; vertical-align: top; border-bottom: #000000 2px solid;">
              <div style="color: #000000;">/s/ Alexander D. Macrae</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.48%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: bottom;">&#160;</td>
            <td style="width: 89.53%; vertical-align: bottom;">
              <div style="color: #000000;">Alexander D. Macrae, M.B., Ch.B., Ph.D.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.48%; vertical-align: top;">&#160;</td>
            <td style="width: 1%; vertical-align: bottom;">&#160;</td>
            <td style="width: 89.53%; vertical-align: bottom;">
              <div style="color: #000000;">President and Chief Executive Officer</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
      <div><br>
      </div>
      <div>KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Alexander D. Macrae, Prathyusha Duraibabu and Scott Willoughby, and each of them, as his or her true and lawful attorney-in-fact and agent with
        the full power of substitution and resubstitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to file
        the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing
        requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitute or
        substitutes, may lawfully do or cause to be done by virtue hereof.</div>
      <div><br>
      </div>
      <div>Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the date indicated.</div>
      <div> <br>
      </div>
      <div>
        <table id="ze8855b4de5e2481a84e721f81d7bff69" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td rowspan="1" style="width: 46%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">&#160;<font style="font-weight: bold;">Signature</font></td>
              <td rowspan="1" colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td rowspan="1" style="width: 26%; font-weight: bold; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">&#160;Ttle</td>
              <td rowspan="1" colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td rowspan="1" style="width: 26%; text-align: center; border-bottom: 2px solid rgb(0, 0, 0);">&#160;<font style="font-weight: bold;">Date</font></td>
            </tr>
            <tr>
              <td rowspan="1" style="width: 46%;">&#160;</td>
              <td rowspan="1" colspan="1" style="width: 1%;">&#160;</td>
              <td rowspan="1" style="width: 26%;">&#160;</td>
              <td rowspan="1" colspan="1" style="width: 1%;">&#160;</td>
              <td rowspan="1" style="width: 26%;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000; font-weight: bold;">
                  <div style="color: rgb(0, 0, 0); background-color: rgb(255, 255, 255); font-weight: normal; font-family: 'Times New Roman',Times,serif; font-style: normal; font-variant: normal; text-transform: none;">/s/ Alexander D. Macrae</div>
                </div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="color: #000000;">President, Chief Executive Officer and Director</div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Alexander D. Macrae, M.B., Ch.B., Ph.D.</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;">
                <div style="color: #000000;">(<font style="font-style: italic;">Principal Executive Officer</font>)</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ Prathyusha Duraibabu</div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Senior Vice President and Chief Financial Officer</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Prathyusha Duraibabu</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;">
                <div style="color: #000000;">(<font style="font-style: italic;">Principal Financial and Accounting Officer</font>)</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ H. Stewart Parker</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;">
                <div style="color: #000000;">Director and Chairman of the Board</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">H. Stewart Parker</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div>
                  <div style="text-align: center; color: #000000;">/s/ Courtney Beers</div>
                </div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Courtney Beers, Ph.D.</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ Robert F. Carey</div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Robert F. Carey</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
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            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center;"><font style="color: #000000;">/s/ </font>Kenneth J. Hillan</div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center;">Kenneth J. Hillan, M.B., Ch.B.</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div>
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                </div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Margaret A. Horn</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ John H. Markels</div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">John H. Markels, Ph.D.</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div>
                  <div style="text-align: center; color: #000000;">/s/ James R. Meyers</div>
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              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">James R. Meyers</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; color: #000000;">/s/ Karen L. Smith</div>
              </td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">Director</td>
              <td colspan="1" style="width: 1%; padding-bottom: 2px;">&#160;</td>
              <td style="width: 26%; padding-bottom: 2px;">
                <div style="text-align: right;">November 12, 2024</div>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;">
                <div style="text-align: center; color: #000000;">Karen L. Smith, M.D., Ph.D., M.B.A., L.L.M.</div>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>
            <tr>
              <td style="width: 46%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
              <td colspan="1" style="width: 1%;">&#160;</td>
              <td style="width: 26%;"><br>
              </td>
            </tr>

        </table>
      </div>
      <div> <br>
      </div>
      <div><br>
      </div>
      <div><br>
      </div>
    </div>
  </div>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ny20037443x2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using Broadridge PROfile 24.9.1.5252
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 5.1</font><br>
    </div>
    <div><br>
      <img src="ny20037443x2_cooley.jpg"></div>
    <div><br>
      <div style="color: #000000;">
        <div style="font-family: 'Times New Roman',Times,serif;">Courtney Tygesson</div>
        <div style="font-family: 'Times New Roman',Times,serif;">+1 312 881 6680</div>
        <div style="font-family: 'Times New Roman',Times,serif;">ctygesson@cooley.com</div>
      </div>
      <div style="color: #000000;"> <br>
      </div>
      <div style="color: #000000;">November 12, 2024</div>
      <div><br>
      </div>
      <div>Sangamo Therapeutics, Inc.</div>
      <div style="text-align: justify;">501 Canal Blvd.</div>
      <div style="text-align: justify;">Richmond, California 94804</div>
      <div><br>
      </div>
      <div style="color: #000000;">Ladies and Gentlemen:</div>
      <div><br>
      </div>
      <div>
        <div style="text-align: justify; color: #000000;">We have acted as counsel to Sangamo Therapeutics, Inc., a Delaware corporation (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221;), in connection with the filing by the
          Company of a registration statement on Form S-8 (the &#8220;<font style="font-weight: bold; font-style: italic;">Registration Statement</font>&#8221;) with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221;)



          covering the offering of up to 11,000,000 shares of its common stock, par value $0.01 per share (the &#8220;<font style="font-weight: bold; font-style: italic;">Shares</font>&#8221;), pursuant to the Company&#8217;s Amended and Restated 2018 Equity Incentive Plan
          (the &#8220;<font style="font-weight: bold; font-style: italic;">Plan</font>&#8221;).</div>
        <div><br>
        </div>
        <div style="text-align: justify; color: #000000;">In connection with this opinion, we have examined and relied upon (a) the Registration Statement and related prospectus, (b) the Company&#8217;s certificate of incorporation and bylaws, each as currently
          in effect, (c) the Plan and (d) such other records, documents, opinions, certificates, memoranda and instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. We have assumed the genuineness
          of all signatures; the authenticity of all documents submitted to us as originals; the conformity to originals of all documents submitted to us as copies; the accuracy, completeness and authenticity of certificates of public officials and the due
          authorization, execution and delivery of all documents by all persons other than the Company where authorization, execution and delivery are prerequisites to the effectiveness thereof. As to certain factual matters, we have relied upon a
          certificate of an officer of the Company and have not independently verified such matters.</div>
        <div><br>
        </div>
      </div>
      <div style="text-align: justify; color: #000000;">Our opinion is expressed only with respect to the General Corporation Law of the State of Delaware.&#160; We express no opinion to the extent that any other laws are applicable to the subject matter hereof
        and express no opinion and provide no assurance as to compliance with any federal or state securities law, rule or regulation.</div>
      <div><br>
      </div>
      <div>
        <div style="text-align: justify; color: #000000;">On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when sold and issued in accordance with the Plan, the Registration Statement and related prospectus,
          will be validly issued, fully paid and nonassessable (except as to shares issued pursuant to deferred payment arrangements, which will be fully paid and nonassessable when such deferred payments are made in full).</div>
        <div><br>
        </div>
      </div>
      <div style="text-align: justify; color: #000000;">This opinion is limited to the matters expressly set forth in this letter, and no opinion has been or should be implied, or may be inferred, beyond the matters expressly stated.&#160; This opinion speaks
        only as to law and facts in effect or existing as of the date hereof, and we have no obligation or responsibility to update or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in
        law that may hereafter occur.</div>
      <div><br>
      </div>
      <div style="color: #000000;">We hereby consent to the filing of this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7
        of the Securities Act of 1933, as amended, or the rules and regulations of the Commission thereunder.</div>
      <div><br>
      </div>
      <div>
        <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div class="BRPFPageFooter" style="width: 100%;">
            <div>
              <div style="text-align: center; font-size: 8pt;">Cooley LLP&#8194; 110 N. Wacker Drive, Suite 4200&#8194; Chicago, IL&#8194; 60606-1511</div>
              <div style="text-align: center; font-size: 8pt;">t: (312) 881-6500&#8194; f: (312) 881-6598&#8194; cooley.com</div>
            </div>
          </div>
          <div class="BRPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div>
          <div style="font-family: 'Times New Roman',Times,serif;"> <img src="ny20037443x2_cooley.jpg"></div>
          <div style="font-family: 'Times New Roman',Times,serif;"> <br>
          </div>
          <div style="font-family: 'Times New Roman',Times,serif;">November 12, 2024</div>
          <div style="font-family: 'Times New Roman',Times,serif;">Page Two</div>
        </div>
        <div><br>
        </div>
        <div style="color: #000000;">Sincerely,</div>
        <div><br>
        </div>
        <div style="color: #000000;">Cooley LLP</div>
        <div><br>
        </div>
        <div>
          <table id="z1e9dc1337c544246a28032616bdd70f2" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

              <tr>
                <td style="width: 2%; padding-bottom: 2px;"><font style="color: #000000;">By:</font></td>
                <td style="width: 49%; border-bottom: 2px solid rgb(0, 0, 0);"><font style="color: #000000;">&#160;/s/ Courtney Tygesson</font>&#160;&#160; <br>
                </td>
                <td style="width: 49%; padding-bottom: 2px;"><br>
                </td>
              </tr>
              <tr>
                <td style="width: 2%;"><br>
                </td>
                <td style="width: 49%;">
                  <div>
                    <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Courtney Tygesson</div>
                  </div>
                </td>
                <td style="width: 49%;"><br>
                </td>
              </tr>

          </table>
        </div>
        <div><br>
        </div>
        <br>
      </div>
    </div>
  </div>
  <div class="BRPFPageFooter" style="width: 100%;">
    <div>
      <div style="text-align: center; font-size: 8pt;">Cooley LLP&#8194; 110 N. Wacker Drive, Suite 4200&#8194; Chicago, IL&#8194; 60606-1511</div>
      <div style="text-align: center; font-size: 8pt;">t: (312) 881-6500&#8194; f: (312) 881-6598&#8194; cooley.com</div>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>ny20037443x2_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using Broadridge PROfile 24.9.1.5252
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
    <div>
      <div style="text-align: right; text-indent: -18pt; margin-left: 18pt; font-weight: bold;">Exhibit 23.1</div>
      <div><br>
      </div>
      <div>
        <div style="text-align: center; color: #000000; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
        <div><br>
        </div>
      </div>
      <div>
        <div style="color: #000000;">We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Amended and Restated Sangamo Therapeutics, Inc. 2018 Equity Incentive Plan of our reports dated March 13, 2024,
          with respect to the consolidated financial statements of Sangamo Therapeutics, Inc., and the effectiveness of internal control over financial reporting of Sangamo Therapeutics, Inc., included in its Annual Report (Form 10-K) for the year ended
          December 31, 2023, filed with the Securities and Exchange Commission.</div>
        <div><br>
        </div>
        <div>
          <table id="z871e53e543584fd1974f2817f65c8bc2" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" border="0" cellpadding="0" cellspacing="0">

              <tr>
                <td style="width: 50.00%;"><br>
                </td>
                <td style="width: 50%;">
                  <div>
                    <div style="text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">/s/ ERNST &amp; YOUNG LLP</div>
                  </div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div>
        <div><br>
        </div>
        <div style="color: #000000;">San Mateo, California</div>
      </div>
      <div style="text-align: justify;">November 12, 2024</div>
      <div style="text-align: justify;"> <br>
      </div>
      <div style="text-align: justify;">
        <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
      <div><br>
      </div>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>ny20037443x2_ex107.htm
<DESCRIPTION>FILING FEES TABLE
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Financial Solutions, Inc.
         Document created using Broadridge PROfile 24.9.1.5252
         Copyright 1995 - 2024 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">
  <div>
    <div style="text-align: right; text-indent: -18pt; margin-left: 18pt; font-weight: bold;">Exhibit 107</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Calculation of Filing Fee Table</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Form S-8</div>
    <div style="text-align: center;">(Form Type)</div>
    <div><br>
    </div>
    <div style="text-align: center; text-indent: 0.05pt; font-weight: bold;">Sangamo Therapeutics, Inc.</div>
    <div><br>
    </div>
    <div style="text-align: center; text-indent: 0.05pt;">(Exact Name of Registrant as Specified in its Charter)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Table 1: Newly Registered Securities</div>
    <div style="text-align: center; font-weight: bold;"> <br>
    </div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z43eaa2731bed4301a43ae7bc23b9c353" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 8.6%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 9.34%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Security Type</div>
          </td>
          <td style="width: 16.41%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Security Class Title</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Fee Calculation</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Rule</div>
          </td>
          <td style="width: 12.51%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Amount Registered</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Proposed</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Maximum</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Offering Price</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Per Unit</div>
          </td>
          <td style="width: 12.51%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Maximum</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Aggregate Offering</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Price</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Fee Rate</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>&#160;</div>
            <div>&#160;</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Amount of</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Registration</div>
            <div style="text-align: center; margin-left: 2.15pt; font-weight: bold;">Fee</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.6%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="margin-left: 2.15pt;">Fees to Be</div>
            <div style="margin-left: 2.15pt;">Paid</div>
          </td>
          <td style="width: 9.34%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="margin-left: 2.15pt;">Equity</div>
          </td>
          <td style="width: 16.41%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="margin-left: 2.15pt;">Common Stock, par</div>
            <div style="margin-left: 2.15pt;">value $0.01 per share</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">Other(1)</div>
          </td>
          <td style="width: 12.51%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">11,000,000(2)</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">$1.9475(1)</div>
          </td>
          <td style="width: 12.51%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">&#160;$21,422,500(1)</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">0.0001531</div>
          </td>
          <td style="width: 10.16%; vertical-align: bottom; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">$3,279.79</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.6%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="3" style="width: 35.91%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: right; margin-left: 2.15pt;">Total Offering Amounts</div>
          </td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">$21,422,500</div>
          </td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">$3,279.79</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.6%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="3" style="width: 35.91%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: right; margin-left: 2.15pt;">Total Fees Previously Paid</div>
          </td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">&#8213;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 8.6%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="3" style="width: 35.91%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: right; margin-left: 2.15pt;">Total Fee Offsets</div>
          </td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">&#8213;</div>
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          <td style="width: 8.6%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td colspan="3" style="width: 35.91%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: right; margin-left: 2.15pt;">Net Fee Due</div>
          </td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 12.51%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
          <td style="width: 10.16%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; margin-left: 2.15pt;">$3,279.79</div>
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    <div>_______________</div>
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          <td style="width: 54pt; vertical-align: top;">(1)</td>
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            <div>Estimated solely for the purposes of calculating the registration fee pursuant to Rule 457(h) and (c) under the Securities Act of 1933, as amended (the &#8220;Securities
              Act&#8221;). The offering price per share and the aggregate offering price are based on the average of the high and low prices of the registrant&#8217;s common stock as reported on The Nasdaq Capital Market on November 7, 2024.</div>
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          <td style="width: 54pt; vertical-align: top;">(2)</td>
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            <div>Pursuant to Rule 416 under the Securities Act, this registration statement shall also cover any additional shares of the registrant&#8217;s common stock that become issuable
              under the plan set forth herein by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of outstanding shares of the registrant&#8217;s common
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