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OTHER BALANCE SHEET DETAILS
 12 Months Ended
Dec. 31, 2024
Balance Sheet Related Disclosures [Abstract]  
OTHER BALANCE SHEET DETAILS OTHER BALANCE SHEET DETAILS
Property and Equipment, Net
Property and equipment, net consist of the following (in thousands):
December 31,
20242023
Laboratory equipment$21,391 $34,630 
Leasehold improvements24,923 29,809 
Furniture and fixtures3,546 4,610 
Manufacturing equipment7,845 7,784 
Construction in progress— 1,087 
57,705 77,920 
Less: accumulated depreciation and amortization(39,818)(51,046)
Property and equipment, net$17,887 $26,874 
Depreciation and amortization expense was $5.1 million and $15.1 million during the years ended December 31, 2024 and 2023, respectively.
During the year ended December 31, 2024, the Company recorded impairment losses of $1.9 million for its laboratory equipment and $0.7 million for its leasehold improvements. During the year ended December 31, 2023, the Company recorded impairment losses of $23.1 million for its leasehold improvements, $8.0 million for its laboratory equipment, $2.3 million for its manufacturing equipment, $1.6 million for its furniture and fixtures, and $1.6 million for its construction in progress.
Intangible Assets
The changes in intangible assets were as follows (in thousands):
December 31,
20242023
Balance at beginning of year$— $50,729 
Foreign currency translation adjustment— 618 
Impairment of indefinite-lived intangible asset— (51,347)
Balance at end of year$— $— 
Goodwill
The changes in goodwill were as follows (in thousands):
December 31,
20242023
Balance at beginning of year$— $37,552 
Foreign currency translation adjustment— 586 
Impairment of goodwill— (38,138)
Balance at end of year$— $— 
Other Accrued Liabilities
Other accrued liabilities consist of the following (in thousands):
December 31,
20242023
Operating lease liabilities – current
$4,313 $4,589 
Accrued professional fees1,368 1,505 
Accrued restructuring charges896 11,733 
Accrued research and development expenses213 3,763 
Other1,405 1,964 
Total other accrued liabilities$8,195 $23,554