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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Operating Activities:    
Net (loss) income $ (85,513) $ (74,545)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,002 3,866
Amortization in operating lease right-of-use assets 2,717 3,360
Stock-based compensation 6,949 9,099
Deferred income tax benefit 0 18
Impairment of long-lived assets 0 5,521
Accretion of discount on marketable securities 0 (273)
Other 35 (4)
Net changes in operating assets and liabilities:    
Interest receivable 0 402
Accounts receivable 3 (9,573)
Prepaid expenses and other assets (3,225) 5,808
Refundable research income tax credits 0 595
Accounts payable and other accrued liabilities 4,300 (6,851)
Accrued compensation and employee benefits 2,481 2,060
Lease liabilities (3,599) (4,081)
Other non-current liabilities 45 36
Deferred revenues 0 774
Net cash used in operating activities (72,805) (63,788)
Investing Activities:    
Maturities of marketable securities 0 1,110
Proceeds from sale of marketable securities 0 34,730
Proceeds from sale of assets classified as held for sale 0 475
Purchases of property and equipment (88) (115)
Net cash (used in) provided by investing activities (88) 36,200
Financing Activities:    
Proceeds from at-the-market offering, net of offering expenses 37,203 0
Proceeds from issuance of common stock, net of offering expenses 21,483 21,924
Taxes paid related to net share settlement of equity awards (2,914) (684)
Proceeds from issuance of common stock under employee stock purchase plan 180 146
Net cash provided by financing activities 55,952 21,386
Effect of exchange rate changes on cash, cash equivalents, and restricted cash 4,051 199
Net decrease in cash, cash equivalents, and restricted cash (12,890) (6,003)
Cash, cash equivalents, and restricted cash, beginning of period 43,418 46,704
Cash, cash equivalents, and restricted cash, end of period 30,528 40,701
Supplemental cash flow disclosures:    
Property and equipment included in unpaid liabilities $ 88 $ 389