    <SEC-DOCUMENT>0001213900-18-011631-index.html : 20180823
    <SEC-HEADER>0001213900-18-011631.hdr.sgml : 20180823
    <ACCEPTANCE-DATETIME>20180823161023
    ACCESSION NUMBER:		0001213900-18-011631
    CONFORMED SUBMISSION TYPE:	F-1/A
    PUBLIC DOCUMENT COUNT:		42
    FILED AS OF DATE:		20180823
    DATE AS OF CHANGE:		20180823

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Tiziana Life Sciences plc
    		CENTRAL INDEX KEY:			0001723069
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			X0
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		F-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-226368
    		FILM NUMBER:		181034874

    	BUSINESS ADDRESS:
    		STREET 1:		3RD FLOOR, 11-12 ST. JAMES'S SQUARE
    		CITY:			LONDON, ENGLAND
    		STATE:			X0
    		ZIP:			SW1Y 4LB
    		BUSINESS PHONE:		0044(0) 207-495-2379

    	MAIL ADDRESS:
    		STREET 1:		3RD FLOOR, 11-12 ST. JAMES'S SQUARE
    		CITY:			LONDON, ENGLAND
    		STATE:			X0
    		ZIP:			SW1Y 4LB
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>F-1/A
    <SEQUENCE>1
    <FILENAME>ff12018a1_tizianalife.htm
    <DESCRIPTION>AMENDMENT NO. 1 TO FORM F-1
    <TEXT>
    Document 1 - file: ff12018a1_tizianalife.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-1.1
    <SEQUENCE>2
    <FILENAME>ff12018a1ex1-1_tiziana.htm
    <DESCRIPTION>FORM OF UNDERWRITING AGREEMENT
    <TEXT>
    Document 2 - file: ff12018a1ex1-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-3.1
    <SEQUENCE>3
    <FILENAME>ff12018a1ex3-1_tiziana.htm
    <DESCRIPTION>MEMORANDUM AND ARTICLES OF ASSOCIATION OF TIZIANA LIFE SCIENCES PLC
    <TEXT>
    Document 3 - file: ff12018a1ex3-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.1
    <SEQUENCE>4
    <FILENAME>ff12018a1ex4-1_tiziana.htm
    <DESCRIPTION>FORM OF DEPOSIT AGREEMENT
    <TEXT>
    Document 4 - file: ff12018a1ex4-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.3
    <SEQUENCE>5
    <FILENAME>ff12018a1ex4-3_tiziana.htm
    <DESCRIPTION>FORM OF REPRESENTATIVE'S WARRANT
    <TEXT>
    Document 5 - file: ff12018a1ex4-3_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>6
    <FILENAME>ff12018a1ex5-1_tiziana.htm
    <DESCRIPTION>OPINION OF COOLEY (UK) LLP
    <TEXT>
    Document 6 - file: ff12018a1ex5-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.1
    <SEQUENCE>7
    <FILENAME>ff12018a1ex10-1_tiziana.htm
    <DESCRIPTION>LICENSE AGREEMENT RELATING TO MILCICLIB BETWEEN NERVIANO MEDICAL SERVICES S.R.L. AND TIZIANA LIFE SCIENCES PLCPLC, DATED JANUARY 2015
    <TEXT>
    Document 7 - file: ff12018a1ex10-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.2
    <SEQUENCE>8
    <FILENAME>ff12018a1ex10-2_tiziana.htm
    <DESCRIPTION>LICENSE AND SUBLICENSE AGREEMENT RELATING TO CD3 (NI-0401) BETWEEN NOVIMMUNE SA AND TIZIANA LIFE SCIENCES PLC, DATED DECEMBER 2014
    <TEXT>
    Document 8 - file: ff12018a1ex10-2_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.3
    <SEQUENCE>9
    <FILENAME>ff12018a1ex10-3_tiziana.htm
    <DESCRIPTION>LICENSE AND SUBLICENSE AGREEMENT RELATING TO IL-6R (NI-1201) BETWEEN NOVIMMUNE SA AND TIZIANA LIFE SCIENCES PLC, DATED DECEMBER 2016
    <TEXT>
    Document 9 - file: ff12018a1ex10-3_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.4
    <SEQUENCE>10
    <FILENAME>ff12018a1ex10-4_tiziana.htm
    <DESCRIPTION>LICENSE AGREEMENT RELATING TO A NOVEL FORMULATION OF FORALUMAB IN A MEDICAL DEVICE FOR NASAL ADMINISTRATION BETWEEN THE BRIGHAM AND WOMEN'S HOSPITAL, INC. AND TIZIANA LIFE SCIENCES PLC, DATED APRIL 2018
    <TEXT>
    Document 10 - file: ff12018a1ex10-4_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.5
    <SEQUENCE>11
    <FILENAME>ff12018a1ex10-5_tiziana.htm
    <DESCRIPTION>ANNUAL LEASE FOR 55 PARK LANE, SUITE 14A, LONDON W1K 1NA, UNITED KINGDOM, DATED JUNE 29, 2018
    <TEXT>
    Document 11 - file: ff12018a1ex10-5_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.6
    <SEQUENCE>12
    <FILENAME>ff12018a1ex10-6_tiziana.htm
    <DESCRIPTION>FIVE-YEAR LEASE FOR 420 LEXINGTON AVENUE, SUITE 2525, NEW YORK, UNITED STATES, DATED AUGUST 2, 2016
    <TEXT>
    Document 12 - file: ff12018a1ex10-6_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.7
    <SEQUENCE>13
    <FILENAME>ff12018a1ex10-7_tiziana.htm
    <DESCRIPTION>ANNUAL LEASE FOR 3085 OLD EASTON ROAD, DOYLESTOWN, PENNSYLVANIA, UNITED STATES, DATED DECEMBER 6, 2017
    <TEXT>
    Document 13 - file: ff12018a1ex10-7_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.8
    <SEQUENCE>14
    <FILENAME>ff12018a1ex10-8_tiziana.htm
    <DESCRIPTION>TIZIANA LIFE SCIENCES PLC EMPLOYEE SHARE OPTION PLAN, WITH NON-EMPLOYEE SUB-PLAN AND US SUB-PLAN, ADOPTED BY THE BOARD ON 23 MARCH 2016 AND APPROVED BY SHAREHOLDERS ON JUNE 30, 2016
    <TEXT>
    Document 14 - file: ff12018a1ex10-8_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.9
    <SEQUENCE>15
    <FILENAME>ff12018a1ex10-9_tiziana.htm
    <DESCRIPTION>CONTRACT OF EMPLOYMENT, DATED MAY 2017, BETWEEN THE REGISTRANT AND DR. KUNWAR SHAILUBHAI
    <TEXT>
    Document 15 - file: ff12018a1ex10-9_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.10
    <SEQUENCE>16
    <FILENAME>ff12018a1ex10-10_tiziana.htm
    <DESCRIPTION>FORM OF DEED OF INDEMNITY FOR BOARD MEMBERS
    <TEXT>
    Document 16 - file: ff12018a1ex10-10_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-21.1
    <SEQUENCE>17
    <FILENAME>ff12018a1ex21-1_tiziana.htm
    <DESCRIPTION>LIST OF SUBSIDIARIES
    <TEXT>
    Document 17 - file: ff12018a1ex21-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>18
    <FILENAME>ff12018a1ex23-1_tiziana.htm
    <DESCRIPTION>CONSENT OF MAZARS LLP, INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM, REGARDING THE FINANCIAL STATEMENTS OF TIZIANA LIFE SCIENCES PLC AS OF DECEMBER 31, 2016 AND 2015 AND FOR EACH OF THE TWO YEARS IN THE PERIOD ENDED DECEMBER 31, 2016
    <TEXT>
    Document 18 - file: ff12018a1ex23-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>ex3-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: ex3-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>ex3-1_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 20 - file: ex3-1_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>ex4-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 21 - file: ex4-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>ex4-1_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 22 - file: ex4-1_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>ex5-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 23 - file: ex5-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>ex10-2_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 24 - file: ex10-2_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>ex10-2_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 25 - file: ex10-2_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>ex10-2_003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 26 - file: ex10-2_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>ex10-2_004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 27 - file: ex10-2_004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>ex10-3_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 28 - file: ex10-3_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>ex10-3_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 29 - file: ex10-3_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>ex10-5_003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 30 - file: ex10-5_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>ex10-6_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 31 - file: ex10-6_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>ex10-7_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 32 - file: ex10-7_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>ex10-8_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 33 - file: ex10-8_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>ex10-9_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 34 - file: ex10-9_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>image_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 35 - file: image_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>36
    <FILENAME>image_004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 36 - file: image_004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>37
    <FILENAME>image_005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 37 - file: image_005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>38
    <FILENAME>image_007.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 38 - file: image_007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>39
    <FILENAME>img_1n.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 39 - file: img_1n.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>40
    <FILENAME>img_3n.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 40 - file: img_3n.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>41
    <FILENAME>img_7n.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 41 - file: img_7n.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>42
    <FILENAME>img_8n.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 42 - file: img_8n.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>