    <SEC-DOCUMENT>0001213900-19-018314-index.html : 20190917
    <SEC-HEADER>0001213900-19-018314.hdr.sgml : 20190917
    <ACCEPTANCE-DATETIME>20190917171909
    ACCESSION NUMBER:		0001213900-19-018314
    CONFORMED SUBMISSION TYPE:	F-1/A
    PUBLIC DOCUMENT COUNT:		13
    FILED AS OF DATE:		20190917
    DATE AS OF CHANGE:		20190917

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Tiziana Life Sciences plc
    		CENTRAL INDEX KEY:			0001723069
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			X0
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		F-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-233020
    		FILM NUMBER:		191097746

    	BUSINESS ADDRESS:
    		STREET 1:		3RD FLOOR, 11-12 ST. JAMES'S SQUARE
    		CITY:			LONDON, ENGLAND
    		STATE:			X0
    		ZIP:			SW1Y 4LB
    		BUSINESS PHONE:		0044(0) 207-495-2379

    	MAIL ADDRESS:
    		STREET 1:		3RD FLOOR, 11-12 ST. JAMES'S SQUARE
    		CITY:			LONDON, ENGLAND
    		STATE:			X0
    		ZIP:			SW1Y 4LB
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>F-1/A
    <SEQUENCE>1
    <FILENAME>ff12019a1_tizianalife.htm
    <DESCRIPTION>AMENDMENT NO. 1 TO FORM F-1
    <TEXT>
    Document 1 - file: ff12019a1_tizianalife.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>2
    <FILENAME>ff12019a1ex5-1_tiziana.htm
    <DESCRIPTION>OPINION OF COOLEY (UK) LLP
    <TEXT>
    Document 2 - file: ff12019a1ex5-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>3
    <FILENAME>ff12019a1ex23-1_tiziana.htm
    <DESCRIPTION>CONSENT OF MAZARS LLP, INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
    <TEXT>
    Document 3 - file: ff12019a1ex23-1_tiziana.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>ex5-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: ex5-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>tiziana_logo.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tiziana_logo.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>image_01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: image_01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>image_02.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: image_02.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>image_011.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: image_011.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>image_03.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: image_03.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>image_04.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: image_04.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>image_05.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: image_05.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>linechart.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: linechart.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>image_06.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: image_06.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>