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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Number of shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Number of options outstanding, including both vested and non-vested options.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Stock-Based Awards (Details) - shares	6 Months Ended
Stock-Based Awards (Details) - shares	Jun. 30, 2025	Jun. 30, 2024	Dec. 31, 2024	Nov. 30, 2024
Stock-based awards
Options outstanding	11,344,962		6,721,967
Stock Option Valuation
Risk-free interest rate (as a percent)	4.32%	3.85%
Expected term (in years)	6 years 2 months 12 days	6 years
Expected volatility (as a percent)	82.71%	81.95%
Expected dividend yield (as a percent)	0.00%	0.00%
2017 Inducement Plan
Stock-based awards
Options outstanding	343,500
2015 Equity Incentive Plan
Stock-based awards
Number of shares available for grant	0
Options outstanding	9,193,958
2015 Equity Incentive Plan \| Restricted stock units
Stock-based awards
Number of shares outstanding	3,134,641
2012 Equity Compensation Plan
Stock-based awards
Number of shares available for grant	0
Options outstanding	218,404
Inducement Plan, 2024
Stock-based awards
Number of shares available for grant	283,500
Number of shares authorized				2,000,000
Options outstanding	1,335,000
Number of shares outstanding	381,500
2025 Equity Incentive Plan
Stock-based awards
Number of shares available for grant	12,701,995
Number of shares authorized	25,532,993
Common shares reserved for future issuance	9,000,000
Options outstanding	254,100
2025 Equity Incentive Plan \| Restricted stock units
Stock-based awards
Number of shares outstanding	69,480
2025 Equity Incentive Plan \| Award remained available for grant under 2015 plan
Stock-based awards
Number of shares available for grant	3,957,232
2025 Equity Incentive Plan \| Award remained available for grant under 2015 plan and 2012 plan
Stock-based awards
Number of shares available for grant	12,575,761