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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Number of shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Number of options outstanding, including both vested and non-vested options.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Stock-Based Awards (Details) - shares	9 Months Ended
Stock-Based Awards (Details) - shares	Sep. 30, 2025	Sep. 30, 2024	Jun. 30, 2025	Dec. 31, 2024	Nov. 30, 2024
Stock Based Awards
Options outstanding	11,454,518			6,721,967
Stock Option Valuation
Risk-free interest rate (as a percent)	4.28%	3.85%
Expected term (in years)	6 years 2 months 12 days	6 years
Expected volatility (as a percent)	82.77%	81.95%
Expected dividend yield (as a percent)	0.00%	0.00%
2025 Equity Incentive Plan
Stock Based Awards
Number of shares available for grant	12,279,431
Number of shares authorized			25,532,993
Common shares reserved for future issuance			9,000,000
Options outstanding	794,760
2025 Equity Incentive Plan \| Award remained available for grant under 2015 plan
Stock Based Awards
Number of shares available for grant			3,957,232
2025 Equity Incentive Plan \| Award remained available for grant under 2015 plan and 2012 plan
Stock Based Awards
Number of shares available for grant			12,575,761
2025 Equity Incentive Plan \| Restricted stock units
Stock Based Awards
Number of shares outstanding	241,840
2024 Inducement Plan
Stock Based Awards
Number of shares available for grant	493,500
Number of shares authorized					2,000,000
Options outstanding	1,172,000
Number of shares outstanding	334,500
2017 Inducement Plan
Stock Based Awards
Options outstanding	343,500
2015 Equity Incentive Plan
Stock Based Awards
Number of shares available for grant	0		0
Options outstanding	9,144,258
2015 Equity Incentive Plan \| Restricted stock units
Stock Based Awards
Number of shares outstanding	3,098,491
2012 Equity Compensation Plan
Stock Based Awards
Number of shares available for grant	0
Options outstanding	0