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Collaboration and License Agreements - Additional Information (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended
--- | --- | --- | ---
Feb. 28, 2023 | Sep. 30, 2024 | Mar. 31, 2024 | Dec. 31, 2023 | Sep. 30, 2023 | Sep. 30, 2024 | Sep. 30, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |
Revenue |  | $ 19,570 |  |  | $ 43,735 | $ 173,384 | $ 87,165
Vertex |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |
Strategic collaboration agreement, term | 4 years |  |  |  |  |  |
Milestone payment |  |  | $ 75,000 | $ 17,500 |  |  |
Stock issued | $ 19,400 |  |  |  |  |  |
Revenue |  | 19,600 |  |  | 43,700 | 172,400 | 87,200
Vertex | Private Placement |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |
Net proceeds from issuance of common stock | $ 26,300 |  |  |  |  |  |
Number of shares purchases in equity investment (in shares) | 1,618,613 |  |  |  |  |  |
Consideration amount | $ 485,000 |  |  |  |  |  |
Vertex | License |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |
Up-front payment | 223,700 |  |  |  |  |  |
Revenue, remaining performance obligation, amount | 232,000 | 53,900 |  | $ 142,800 |  | 53,900 |
Premium | $ 6,900 |  |  |  |  |  |
Vertex | Collaboration service revenue |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |
Revenue |  | 2,600 |  |  | 3,900 | 12,200 | 12,300
Vertex | Recognition of upfront and milestone payments |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |
Revenue |  | $ 17,000 |  |  | $ 39,800 | $ 17,400 | $ 74,900

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