<SEC-DOCUMENT>0001415889-25-019677.txt : 20250711
<SEC-HEADER>0001415889-25-019677.hdr.sgml : 20250711
<ACCEPTANCE-DATETIME>20250711172521
ACCESSION NUMBER:		0001415889-25-019677
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250709
FILED AS OF DATE:		20250711
DATE AS OF CHANGE:		20250711

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROCKLAGE SCOTT M
		CENTRAL INDEX KEY:			0001219014
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40969
		FILM NUMBER:		251119766

	MAIL ADDRESS:	
		STREET 1:		C/O 5AM VENTURE MANAGEMENT, LLC
		STREET 2:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Schwab Andrew J.
		CENTRAL INDEX KEY:			0001598549
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40969
		FILM NUMBER:		251119765

	MAIL ADDRESS:	
		STREET 1:		C/O 5AM VENTURE MANAGEMENT, LLC
		STREET 2:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Ventures V, L.P.
		CENTRAL INDEX KEY:			0001674324
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40969
		FILM NUMBER:		251119770

	BUSINESS ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111
		BUSINESS PHONE:		(415) 993-8565

	MAIL ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Partners V, LLC
		CENTRAL INDEX KEY:			0001791889
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40969
		FILM NUMBER:		251119769

	BUSINESS ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111
		BUSINESS PHONE:		(415) 993-8565

	MAIL ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Opportunities I, L.P.
		CENTRAL INDEX KEY:			0001753000
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40969
		FILM NUMBER:		251119768

	BUSINESS ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111
		BUSINESS PHONE:		(415) 993-8565

	MAIL ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			5AM Opportunities I (GP), LLC
		CENTRAL INDEX KEY:			0001790778
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40969
		FILM NUMBER:		251119767

	BUSINESS ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111
		BUSINESS PHONE:		(415) 993-8565

	MAIL ADDRESS:	
		STREET 1:		4 EMBARCADERO CENTER, SUITE 3110
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94111

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Entrada Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001689375
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				813983399
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE DESIGN CENTER PLACE
		STREET 2:		SUITE 17-500
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		857-305-1825

	MAIL ADDRESS:	
		STREET 1:		ONE DESIGN CENTER PLACE
		STREET 2:		SUITE 17-500
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CycloPorters, Inc.
		DATE OF NAME CHANGE:	20161104
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
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<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-07-09</periodOfReport>

    <issuer>
        <issuerCik>0001689375</issuerCik>
        <issuerName>Entrada Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>TRDA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001674324</rptOwnerCik>
            <rptOwnerName>5AM Ventures V, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 5AM VENTURE MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>4 EMBARCADERO CENTER, SUITE 3110</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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        </reportingOwnerRelationship>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001791889</rptOwnerCik>
            <rptOwnerName>5AM Partners V, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 5AM VENTURE MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>4 EMBARCADERO CENTER, SUITE 3110</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001753000</rptOwnerCik>
            <rptOwnerName>5AM Opportunities I, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 5AM VENTURE MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>4 EMBARCADERO CENTER, SUITE 3110</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
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            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001790778</rptOwnerCik>
            <rptOwnerName>5AM Opportunities I (GP), LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 5AM VENTURE MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>4 EMBARCADERO CENTER, SUITE 3110</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
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            <isTenPercentOwner>1</isTenPercentOwner>
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            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001219014</rptOwnerCik>
            <rptOwnerName>ROCKLAGE SCOTT M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 5AM VENTURE MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>4 EMBARCADERO CENTER, SUITE 3110</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
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            <isTenPercentOwner>1</isTenPercentOwner>
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            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001598549</rptOwnerCik>
            <rptOwnerName>Schwab Andrew J.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 5AM VENTURE MANAGEMENT, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>4 EMBARCADERO CENTER, SUITE 3110</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
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            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-07-09</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>20065</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>7.502</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3163066</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-07-09</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6935</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>7.502</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1093313</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By 5AM Opportunities I, L.P.</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares are held by 5AM Ventures V, L.P. (&quot;5AM V&quot;). 5AM Partners V, LLC (&quot;5AM Partners&quot;) is the sole general partner of 5AM V. Dr. Kush Parmar, Andrew J. Schwab and Dr. Scott M. Rocklage are managing members of 5AM Partners and may be deemed to have shared voting and investment power over the shares beneficially owned by 5AM V. Each of 5AM Partners, Mr. Schwab and Dr. Rocklage disclaims beneficial ownership of the shares of Common Stock held by 5AM V, except to the extent of its or his pecuniary interest therein. Dr. Parmar is a director of the Issuer and files separate Section 16 reports.</footnote>
        <footnote id="F2">Shares are held by 5AM Opportunities I, L.P. (&quot;Opportunities&quot;). 5AM Opportunities I (GP), LLC (&quot;Opportunities GP&quot;) is the sole general partner of Opportunities. Andrew J. Schwab and Dr. Kush Parmar are managing members of Opportunities GP and may be deemed to have shared voting and investment power over the shares beneficially owned by Opportunities. Each of Opportunities GP and Mr. Schwab disclaims beneficial ownership of the shares of Common Stock held by Opportunities, except to the extent of its or his pecuniary interest therein. Dr. Parmar is a director of the Issuer and files separate Section 16 reports.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>5AM Ventures V, L.P., By: 5AM Partners V, LLC, its General Partner, By /s/ Scott M. Rocklage, Managing Member</signatureName>
        <signatureDate>2025-07-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM Partners V, LLC, By /s/ Scott M. Rocklage, Managing Member</signatureName>
        <signatureDate>2025-07-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM Opportunities I, L.P., By: 5AM Opportunities I (GP),LLC, its General Partner, By /s/ Kush Parmar, Managing Member</signatureName>
        <signatureDate>2025-07-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>5AM Opportunities I (GP), LLC, By /s/ Kush Parmar, Managing Member</signatureName>
        <signatureDate>2025-07-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Scott M. Rocklage</signatureName>
        <signatureDate>2025-07-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Andrew J. Schwab</signatureName>
        <signatureDate>2025-07-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
