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Significant Accounting Policies - Additional Information (Detail) (USD $)
 3 Months Ended 6 Months Ended 12 Months Ended 1 Months Ended 6 Months Ended 18 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Dec. 31, 2013
Jun. 30, 2014
Certificates of Deposit [Member]
Dec. 31, 2013
Certificates of Deposit [Member]
May 31, 2014
Pfizer License Agreement [Member]
Jun. 30, 2013
Pfizer License Agreement [Member]
Up-Front Payment Arrangement [Member]
Mar. 31, 2013
Pfizer License Agreement [Member]
Up-Front Payment Arrangement [Member]
Jun. 30, 2014
Minimum [Member]
Jun. 30, 2014
Maximum [Member]
Schedule Of Accounting Policies [Line Items]                        
Restricted cash           $ 83,000 $ 83,000          
Carrying value of cash held in money market fund 64,100,000   64,100,000   2,200,000              
Property and Equipment useful lives                     1 year 5 years
Property and equipment, basis of valuation     Cost                  
Property and equipment, depreciation method     Straight-line basis                  
Impairment of long-lived assets to be disposed of     0   0              
Long lived assets held for sale 0   0   0              
Up-front payment received recognized as revenue                 3,800,000 22,500,000    
Joint steering committees period                   1 year 6 months    
Revenue $ 15,027,004 $ 55,074 $ 15,027,004 $ 3,862,665       $ 15,000,000        
Share-based compensation arrangement by share-based payment award, option grant period     6 years 3 months                  
Share-based compensation arrangement by share-based payment award, Option granted term                       10 years