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Research and License Agreements - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 18 Months Ended
Feb. 29, 2016
Jun. 30, 2015
May 31, 2014
Oct. 31, 2011
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Mar. 31, 2013
Dec. 31, 2015
Research and Development Arrangement, Contract to Perform for Others [Line Items]                    
Milestone license fees recorded                   $ 2,000,000
Accrued liability paid for research agreement $ 2,000,000                  
Research and development expenses         $ 5,781,176 $ 7,842,884 $ 11,299,898 $ 13,050,614    
University Of Basel Agreement [Member]                    
Research and Development Arrangement, Contract to Perform for Others [Line Items]                    
Percentage of obligations payable for all future milestone and royalty payments received with respect to rivipansel             10.00%      
Milestone license fees recorded                   $ 2,000,000
Pfizer License Agreement [Member]                    
Research and Development Arrangement, Contract to Perform for Others [Line Items]                    
Potential milestone payments upon the achievement of specified development milestones       $ 115,000,000            
Potential milestone payments upon the achievement of specified regulatory milestones       70,000,000            
Potential milestone payments upon the achievement specified levels of annual net sales of licensed products       135,000,000            
Payment made on execution of milestone agreement       $ 22,500,000            
Period of up-front payment             1 year 6 months      
Revenue   $ 20,000,000 $ 15,000,000              
Pfizer License Agreement [Member] | Up-Front Payment Arrangement [Member]                    
Research and Development Arrangement, Contract to Perform for Others [Line Items]                    
Amount received and recognized as revenue                 $ 22,500,000