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Research and License Agreements - Additional Information (Detail)
1 Months Ended 9 Months Ended 18 Months Ended
Feb. 29, 2016
USD ($)
Jun. 30, 2015
USD ($)
May 31, 2014
USD ($)
Oct. 31, 2011
USD ($)
item
Sep. 30, 2016
Mar. 31, 2013
USD ($)
Dec. 31, 2015
USD ($)
Research and License Agreements              
Milestone license fee liability             $ 2,000,000
License Agreement | Pfizer | Up-Front Payment Arrangement              
Research and License Agreements              
Upfront payment received       $ 22,500,000      
Upfront payment revenue recognized           $ 22,500,000  
Recognition period of up-front payment           1 year 6 months  
Research Services Agreement | University Of Basel              
Research and License Agreements              
Royalty payment due against license fees received (as a percent)         10.00%    
Milestone license fee liability             $ 2,000,000
Payment of milestone liability $ 2,000,000            
Achievement Of Specified Development Milestone | License Agreement | Pfizer              
Research and License Agreements              
Number of indications | item       2      
Milestone revenue   $ 20,000,000 $ 15,000,000        
Achievement Of Specified Development Milestone | License Agreement | Pfizer | Maximum              
Research and License Agreements              
Potential milestone payments       $ 115,000,000      
Achievement Of Specified Regulatory Milestone | License Agreement | Pfizer              
Research and License Agreements              
Number of indications | item       2      
Achievement Of Specified Regulatory Milestone | License Agreement | Pfizer | Maximum              
Research and License Agreements              
Potential milestone payments       $ 70,000,000      
Achievement Of Specified Levels Of Annual Net Sales Of Licensed Products | License Agreement | Pfizer | Maximum              
Research and License Agreements              
Potential milestone payments       $ 135,000,000