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Statements of Operations and Comprehensive Loss - USD ($) | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Statements of Operations and Comprehensive (Loss) Income |  |  |
Revenue | $ 18,500 | $ 20,070,750 | $ 15,027,004
Costs and expenses: |  |  |
Research and development expense | 23,281,820 | 25,050,179 | 19,571,073
General and administrative expense | 8,650,165 | 7,805,396 | 6,595,738
Total costs and expenses | 31,931,985 | 32,855,575 | 26,166,811
Loss from operations | (31,913,485) | (12,784,825) | (11,139,807)
Other income | 103,647 | 15,327 | 18,241
Net loss and comprehensive loss | $ (31,809,838) | $ (12,769,498) | $ (11,121,566)
Basic and diluted net loss per common share (in dollars per share) | $ (1.50) | $ (0.67) | $ (0.60)
Basic and diluted weighted average number of common shares (in shares) | 21,256,312 | 19,010,587 | 18,452,252

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