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Statements of Stockholders' Equity - USD ($) | Series A-1 Convertible Preferred Stock | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2013 | $ 30,726 | $ 1,428 | $ 66,150,674 | $ (63,275,409) | $ 2,907,419
Balance, shares at Dec. 31, 2013 | 30,726,326 | 1,426,593 |  |  |
Issuance of common stock, net of issuance costs |  | $ 8,050 | 57,240,169 |  | 57,248,219
Issuance of common stock, net of issuance costs, shares |  | 8,050,000 |  |  |
Exercise of options |  | $ 157 | 134,134 |  | 134,291
Exercise of options, shares |  | 157,886 |  |  |
Conversion of preferred stock to common stock | $ (30,726) | $ 9,305 | 21,421 |  |
Conversion of preferred stock to common stock, shares | (30,726,326) | 9,305,359 |  |  |
Stock-based compensation |  |  | 1,635,065 |  | 1,635,065
Net loss |  |  |  | (11,121,566) | (11,121,566)
Balance at Dec. 31, 2014 |  | $ 18,940 | 125,181,463 | (74,396,975) | 50,803,428
Balance, shares at Dec. 31, 2014 |  | 18,939,838 |  |  |
Exercise of options |  | $ 109 | 114,012 |  | 114,121
Exercise of options, shares |  | 110,366 |  |  |
Stock-based compensation |  |  | 2,323,603 |  | 2,323,603
Net loss |  |  |  | (12,769,498) | (12,769,498)
Balance at Dec. 31, 2015 |  | $ 19,049 | 127,619,078 | (87,166,473) | 40,471,654
Balance, shares at Dec. 31, 2015 |  | 19,050,204 |  |  |
Issuance of common stock, net of issuance costs |  | $ 4,146 | 23,597,809 |  | 23,601,955
Issuance of common stock, net of issuance costs, shares |  | 4,145,584 |  |  |
Exercise of options and warrants |  | $ 54 | 72,539 |  | 72,593
Exercise of options and warrants, shares |  | 54,235 |  |  |
Stock-based compensation |  |  | 2,964,767 |  | 2,964,767
Net loss |  |  |  | (31,809,838) | (31,809,838)
Balance at Dec. 31, 2016 |  | $ 23,249 | $ 154,254,193 | $ (118,976,311) | $ 35,301,131
Balance, shares at Dec. 31, 2016 |  | 23,250,023 |  |  |

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