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Stockholders' Equity - Stock-Based Compensation Expense (Detail) - USD ($) | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Stock-based compensation expense |  |  |
Total stock-based compensation expense | $ 2,964,767 | $ 2,323,603 | $ 1,635,065
Research and Development |  |  |
Stock-based compensation expense |  |  |
Total stock-based compensation expense | 1,033,005 | 802,329 | 512,345
General and Administrative Expense |  |  |
Stock-based compensation expense |  |  |
Total stock-based compensation expense | $ 1,931,762 | $ 1,521,274 | $ 1,122,720

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