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Summary of Significant Accounting Policies (Details)	1 Months Ended		3 Months Ended		12 Months Ended				18 Months Ended
	Aug. 31, 2015 USD ($)	May 31, 2014 USD ($)	Mar. 31, 2013 USD ($)	Dec. 31, 2011 USD ($)	Dec. 31, 2016 USD ($) segment item	Dec. 31, 2015 USD ($) item	Dec. 31, 2014 USD ($)	Dec. 31, 2012 USD ($)	Mar. 31, 2013
Fair Value Measurements
Number Of Operating Segments | segment					1
Assets measured at fair value levels 2 or 3					$ 0	$ 0
Liabilities measured at fair value levels 2 or 3					0	0
Carrying value of cash held in money market fund					$ 38,000,000	$ 45,500,000
Impairment of Long-Lived Assets
Number of long-lived assets determined to be impaired | item					0	0
Assets held for sale					$ 0	$ 0
Share-based Compensation
Expected term					6 years 3 months
Maximum
Share-based Compensation
Expected term					10 years
Pfizer | License Agreement
Revenue Recognition
Milestone revenue	$ 20,000,000	$ 15,000,000			$ 0	$ 20,000,000	$ 15,000,000
Number of milestones met | item					0
Pfizer | License Agreement | Up-Front Payment Arrangement
Revenue Recognition
Upfront payment revenue recognized			$ 22,500,000	$ 22,500,000				$ 22,500,000
Recognition period of up-front payment									1 year 6 months

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