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Income Taxes - Additional Information (Detail) - USD ($)	Dec. 31, 2016	Dec. 31, 2015
NOL to be recognized in APIC when realized	$ 250,359
Unrecognized tax benefits	0	$ 0
Research tax credit carryforward
Tax credits available to carry forward	7,394,601
Orphan drug credit carryforward
Tax credits available to carry forward	7,593,921
U.S. Federal And State
Net operating losses	$ 87,591,753

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Amount of net operating losses to be recognized through additional paid-in-capital when realized.

+ References

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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32559-109319

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-Publisher FASB
-Name Accounting Standards Codification
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-URI http://asc.fasb.org/extlink&oid=6527854

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