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Research and License Agreements - Additional Information (Detail)
1 Months Ended 3 Months Ended 12 Months Ended 18 Months Ended
Feb. 29, 2016
USD ($)
Aug. 31, 2015
USD ($)
Nov. 30, 2014
USD ($)
item
May 31, 2014
USD ($)
Oct. 31, 2011
USD ($)
item
Feb. 29, 2004
Mar. 31, 2013
USD ($)
Dec. 31, 2011
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2012
USD ($)
Mar. 31, 2013
Research and License Agreements                          
Milestone license fee liability                   $ 2,000,000      
Research and Development Expense                 $ 23,281,820 25,050,179 $ 19,571,073    
License Agreement | Pfizer                          
Research and License Agreements                          
Milestone revenue   $ 20,000,000   $ 15,000,000         0 20,000,000 $ 15,000,000    
License Agreement | Pfizer | Up-Front Payment Arrangement                          
Research and License Agreements                          
Upfront payment received         $ 22,500,000                
Upfront payment revenue recognized             $ 22,500,000 $ 22,500,000       $ 22,500,000  
Recognition period of up-front payment                         1 year 6 months
License Agreement | Uni Quest Pty Limited                          
Research and License Agreements                          
Number of method-of-use patents under exclusive rights license agreement | item     2                    
Milestone payment obligation     $ 2,000,000                    
License upfront fees     $ 20,000                    
Research and Development Expense                 0 0      
Research Services Agreement | University Of Basel                          
Research and License Agreements                          
Royalty payment due against license fees received (as a percent)           10.00%              
Milestone license fee liability                 $ 0 $ 2,000,000      
Payment of milestone liability $ 2,000,000                        
Achievement Of Specified Development Milestone | License Agreement | Pfizer                          
Research and License Agreements                          
Number of indications | item         2                
Achievement Of Specified Development Milestone | License Agreement | Pfizer | Maximum                          
Research and License Agreements                          
Potential milestone payments         $ 115,000,000                
Achievement Of Specified Regulatory Milestone | License Agreement | Pfizer                          
Research and License Agreements                          
Number of indications | item         2                
Achievement Of Specified Regulatory Milestone | License Agreement | Pfizer | Maximum                          
Research and License Agreements                          
Potential milestone payments         $ 70,000,000                
Achievement Of Specified Levels Of Annual Net Sales Of Licensed Products | License Agreement | Pfizer | Maximum                          
Research and License Agreements                          
Potential milestone payments         $ 135,000,000