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Statements of Cash Flows - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating activities      
Net loss $ (31,809,838) $ (12,769,498) $ (11,121,566)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 190,540 191,484 158,708
Loss on disposal of property and equipment   8,001 1,424
Stock-based compensation expense 2,964,767 2,323,603 1,635,065
Changes in assets and liabilities      
Prepaid expenses and other current assets (36,693) 474,439 1,656,823
Prepaid research and development expenses (63,000)   (696,531)
Deposits (52,320)    
Accounts payable 1,000,975 (309,792) (270,867)
Accrued expenses and bonuses (2,504,179) 1,693,238 4,459,292
Deferred rent 578,483 146,635 (103,935)
Net cash used in operating activities (29,731,265) (8,241,890) (4,281,587)
Investing activities      
Purchases of property and equipment (704,202) (268,594) (212,603)
Net cash used in investing activities (704,202) (268,594) (212,603)
Financing activities      
Proceeds from issuance of common stock, net of issuance costs 23,601,955   57,248,219
Proceeds from exercise of stock options 72,593 114,121 134,291
Net cash provided by financing activities 23,674,548 114,121 57,382,510
Net change in cash and cash equivalents (6,760,919) (8,396,363) 52,888,320
Cash and cash equivalents, beginning of period 46,802,560 55,198,923 2,310,603
Cash and cash equivalents, end of period 40,041,641 $ 46,802,560 55,198,923
Supplemental disclosure of cash flow information      
Cash paid for taxes     80,000
Non-cash investing and financing activities      
Property asset acquisition included in accrued expenses $ 21,292    
Series A-1 Convertible Preferred Stock      
Non-cash investing and financing activities      
Conversion of Series A convertible preferred stock to common stock     $ 38,805,055