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Stockholders Equity (Tables)

12 Months Ended

Dec. 31, 2016

Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

12/31/2016		12/31/2015
NUMBER OF SHARES		NUMBER OF SHARES		EXERCISE
UNDERLYING OUTSTANDING		UNDERLYING OUTSTANDING		PRICE			EXPIRATION
WARRANTS		WARRANTS		PER SHARE			DATE
236,632		259,907		$	0.33		July 18, 2018
301,986		301,986			0.33		January 16, 2019
15,250		15,250			0.33		January 30, 2019
-		1,544			25.92		October 13, 2016

Stock-Based Compensation Expense

			2016			2015			2014
Research and development expense			$	1,033,005		$	802,329		$	512,345
General and administrative expense				1,931,762			1,521,274			1,122,720
Total stock-based compensation expense			$	2,964,767		$	2,323,603		$	1,635,065

2003 Stock Incentive Plan

Company's Stock Option Activity

							WEIGHTED-AVERAGE
				WEIGHTED-			REMAINING		AGGREGATE
		OUTSTANDING		AVERAGE			CONTRACTUAL TERM		INTRINSIC VALUE
		OPTIONS		EXERCISE PRICE			(YEARS)		(IN THOUSANDS)
Outstanding as of December 31, 2015		758,187		$	1.27		4.2
Options exercised		(28,368)			1.58
Options forfeited		—			—
Outstanding as of December 31, 2016		729,819			1.26		3.2		$	3,536
Vested or expected to vest as of December 31, 2016		729,801			1.26		3.2		$	3,536
Exercisable as of December 31, 2016		729,240			1.25		3.2		$	3,534

2013 Equity Incentive Plan

Company's Stock Option Activity

								WEIGHTED-
					WEIGHTED-			AVERAGE		AGGREGATE
					AVERAGE			REMAINING		INTRINSIC
		OUTSTANDING			EXERCISE			CONTRACTUAL		VALUE (IN
		OPTIONS			PRICE			TERM(YEARS)		THOUSANDS)
Outstanding as of December 31, 2015			1,470,338		$	8.26		8.5
Options granted			627,250			5.36
Options exercised			(3,500)			7.95
Options forfeited			(27,983)			6.28
Outstanding as of December 31, 2016			2,066,105			7.41		7.9		$	505
Vested or expected to vest as of December 31, 2016			2,057,409			7.41		7.9		$	500
Exercisable as of December 31, 2016			910,202			8.26		7.4		$	1

Weighted-Average Fair Value of Options Granted

		2016		2015		2014
Expected term		6.25 years		6.25 years		6.25 years
Expected volatility		68.98%		80.76%		90.27%
Risk-free interest rate		1.70%		1.70%		2.14%
Expected dividend yield		0%		0%		0%

Summary of RSU Activity

The following is a summary of RSU activity for the 2013 Plan for the year ended December 31, 2016:

					WEIGHTED-AVERAGE
			NUMBER		GRANT DATE
		OF SHARES				FAIR VALUE
Unvested at December 31, 2015			4,833		$	7.62
Granted			14,500			4.61
Forfeited			—			—
Vested			2,417			7.62
Unvested at December 31, 2016			16,916			5.04

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