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Statements of Operations and Comprehensive Loss - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Statements of Operations and Comprehensive (Loss) Income      
Revenue $ 18,500 $ 20,070,750 $ 15,027,004
Costs and expenses:      
Research and development expense 23,281,820 25,050,179 19,571,073
General and administrative expense 8,650,165 7,805,396 6,595,738
Total costs and expenses 31,931,985 32,855,575 26,166,811
Loss from operations (31,913,485) (12,784,825) (11,139,807)
Other income 103,647 15,327 18,241
Net loss and comprehensive loss $ (31,809,838) $ (12,769,498) $ (11,121,566)
Basic and diluted net loss per common share (in dollars per share) $ (1.50) $ (0.67) $ (0.60)
Basic and diluted weighted average number of common shares (in shares) 21,256,312 19,010,587 18,452,252