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Statements of Cash Flows - USD ($)
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Operating activities    
Net loss $ (7,931,313) $ (7,554,978)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 54,339 47,234
Stock-based compensation expense 842,847 727,547
Changes in assets and liabilities    
Prepaid expenses and other current assets (218,560) (241,555)
Accounts payable (1,063,049) 1,007,159
Accrued expenses and bonuses (748,402) (3,221,593)
Deferred rent 2,523 6,496
Net cash used in operating activities (9,061,615) (9,229,690)
Investing activities    
Purchases of property and equipment (62,969) (17,270)
Net cash used in investing activities (62,969) (17,270)
Financing activities    
Proceeds from issuance of common stock, net of issuance costs 3,668,043 1,238,619
Proceeds from exercise of stock options 5,478 35,891
Net cash provided by financing activities 3,673,521 1,274,510
Net change in cash and cash equivalents (5,451,063) (7,972,450)
Cash and cash equivalents, beginning of period 40,041,641 46,802,560
Cash and cash equivalents, end of period 34,590,578 38,830,110
Non-cash investing and financing activities    
Property acquisition included in accounts payable $ 9,553  
Issuance costs associated with the at-the-market financing included in accounts payable and accrued expenses   $ 150,767