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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($) | Dec. 31, 2017 | Dec. 31, 2016
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Deferred tax assets: |  |
Net operating loss carryforward | $ 30,813,509 | $ 34,451,814
Capitalized start-up costs | 1,695,688 | 2,708,479
Patent amortization | 135,358 | 216,203
Research and orphan drug credits | 21,293,509 | 14,988,522
Deferred rent | 71,938 | 123,744
Deferred compensation | 2,274,885 | 2,107,964
Other | 69,906 | 70,511
Total gross deferred tax assets | 56,354,793 | 54,667,237
Valuation allowance | $ (56,354,793) | $ (54,667,237)

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