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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2017
Income Taxes |
Schedule of Gross Deferred Tax Asset and Related Valuation Allowance |
|  | 2017 |  | 2016 |
Deferred tax assets: |  |  |  |  |  |  |
Net operating loss carryforward |  | $ | 30,813,509 |  | $ | 34,451,814 |
Capitalized start-up costs |  |  | 1,695,688 |  |  | 2,708,479 |
Patent amortization |  |  | 135,358 |  |  | 216,203 |
Research and orphan drug credits |  |  | 21,293,509 |  |  | 14,988,522 |
Deferred rent |  |  | 71,938 |  |  | 123,744 |
Deferred compensation |  |  | 2,274,885 |  |  | 2,107,964 |
Other |  |  | 69,906 |  |  | 70,511 |
Total gross deferred tax assets |  |  | 56,354,793 |  |  | 54,667,237 |
Valuation allowance |  |  | (56,354,793) |  |  | (54,667,237) |
Deferred tax assets |  |  | — |  |  | — |
Deferred tax liabilities: |  |  |  |  |  |  |
Depreciation |  |  | — |  |  | — |
Total deferred tax liabilities |  |  | — |  |  | — |
Net deferred tax assets |  | $ | — |  | $ | — |
Schedule of Reconciliations Between Statutory Federal Income Tax Rate and Effective Income Tax Rate of Income Tax Expense |
|  | 2017 |  | 2016 |  | 2015 |
U.S. Federal statutory tax rate |  | 34.0 | % | 34.0 | % | 34.0 | %
State taxes |  | 4.4 |  | 4.6 |  | 3.7 |
Research credit |  | 1.3 |  | 1.0 |  | 5.6 |
Orphan drug credit |  | 11.5 |  | 9.0 |  | 11.5 |
Other |  | 0.3 |  | — |  | — |
Stock-based compensation |  | (0.7) |  | (0.7) |  | (1.8) |
Change in valuation allowance |  | (5.1) |  | (47.9) |  | (53.0) |
Effective change due to corporate tax rate reduction |  | (45.7) |  | — |  | — |
Provision for income taxes |  | — | % | — | % | — | %

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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