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Stockholders Equity (Tables) | 12 Months Ended
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Dec. 31, 2017
Common Stock Warrants |
Number of Shares |  | Exercise |  |
Underlying Outstanding |  | Price |  | Expiration |
Warrants |  | Per Share |  | Date |
236,632 |  | $ | 0.33 |  | July 18, 2018 |
301,986 |  |  | 0.33 |  | January 16, 2019 |
15,250 |  |  | 0.33 |  | January 30, 2019 |
Stock-Based Compensation Expense |
|  | 2017 |  | 2016 |  | 2015
Research and development expense |  | $ | 1,280,909 |  | $ | 1,033,005 |  | $ | 802,329
General and administrative expense |  |  | 2,479,893 |  |  | 1,931,762 |  |  | 1,521,274
Total stock-based compensation expense |  | $ | 3,760,802 |  | $ | 2,964,767 |  | $ | 2,323,603
2003 Stock Incentive Plan |
Company's Stock Option Activity |
|  |  |  |  |  | Weighted-Average |  |  |  |
|  |  |  |  |  | Remaining |  | Aggregate |
|  | Outstanding |  | Weighted-Average |  | Contractual Term |  | Intrinsic Value |
|  | Options |  | Exercise Price |  | (Years) |  | (In thousands) |
Outstanding as of December 31, 2016 |  | 729,819 |  | $ | 1.26 |  | 3.2 |  |  |  |
Options exercised |  | (16,608) |  |  | 1.65 |  |  |  |  |  |
Options forfeited |  | — |  |  | — |  |  |  |  |  |
Outstanding as of December 31, 2017 |  | 713,211 |  |  | 1.25 |  | 2.2 |  | $ | 11,086 |
Vested as of December 31, 2017 |  | 713,211 |  |  | 1.25 |  | 2.2 |  | $ | 11,086 |
Exercisable as of December 31, 2017 |  | 713,211 |  |  | 1.25 |  | 2.2 |  | $ | 11,086 |
2013 Equity Incentive Plan |
Company's Stock Option Activity |
|  |  |  |  |  |  |  | WEIGHTED- |  |  |  |
|  |  |  |  | WEIGHTED- |  | AVERAGE |  | AGGREGATE |
|  |  |  | AVERAGE |  | REMAINING |  | INTRINSIC |
|  | OUTSTANDING |  | EXERCISE |  | CONTRACTUAL |  | VALUE (IN |
|  | OPTIONS |  | PRICE |  | TERM(YEARS) |  | THOUSANDS) |
Outstanding as of December 31, 2016 |  |  | 2,066,105 |  | $ | 7.41 |  | 7.9 |  |  |  |
Options granted |  |  | 674,738 |  |  | 7.03 |  |  |  |  |  |
Options exercised |  |  | (54,521) |  |  | 6.35 |  |  |  |  |  |
Options forfeited |  |  | (22,159) |  |  | 7.35 |  |  |  |  |  |
Outstanding as of December 31, 2017 |  |  | 2,664,163 |  |  | 7.34 |  | 7.4 |  | $ | 25,091 |
Vested or expected to vest as of December 31, 2017 |  |  | 2,664,163 |  |  | 7.34 |  | 7.4 |  | $ | 25,091 |
Exercisable as of December 31, 2017 |  |  | 1,569,935 |  |  | 7.81 |  | 6.5 |  | $ | 14,079 |
Weighted-Average Fair Value of Options Granted |
|  | 2017 |  | 2016 |  | 2015
Expected term |  | 6.25 years |  | 6.25 years |  | 6.25 years
Expected volatility |  | 75.20% |  | 68.98% |  | 80.76%
Risk-free interest rate |  | 2.08% |  | 1.70% |  | 1.70%
Expected dividend yield |  | 0% |  | 0% |  | 0%
Summary of RSU Activity | The following is a summary of RSU activity for the 2013 Plan for the year ended December 31, 2017:
|  |  |  |  | Weighted-Average |
|  |  | Number |  | Grant Date |
|  | of Shares |  |  | Fair Value |
Unvested at December 31, 2016 |  |  | 16,916 |  | $ | 5.04 |
Granted |  |  | — |  |  | — |
Forfeited |  |  | — |  |  | — |
Vested |  |  | 7,249 |  |  | 5.61 |
Unvested at December 31, 2017 |  |  | 9,667 |  |  | 4.61 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6784392&loc=d3e188667-122775 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 50 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=68057994&loc=d3e25284-112666 + Details
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