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Statements of Stockholders' Equity - USD ($) | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Total
--- | --- | --- | --- | ---
Balance at Dec. 31, 2014 | $ 18,940 | $ 125,181,463 | $ (74,396,975) | $ 50,803,428
Balance, shares at Dec. 31, 2014 | 18,939,838 |  |  |
Exercise of options and warrants | $ 109 | 114,012 |  | 114,121
Exercise of options and warrants, shares | 110,366 |  |  |
Stock-based compensation |  | 2,323,603 |  | 2,323,603
Net loss |  |  | (12,769,498) | (12,769,498)
Balance at Dec. 31, 2015 | $ 19,049 | 127,619,078 | (87,166,473) | 40,471,654
Balance, shares at Dec. 31, 2015 | 19,050,204 |  |  |
Issuance of common stock, net of issuance costs | $ 4,146 | 23,597,809 |  | 23,601,955
Issuance of common stock, net of issuance costs, shares | 4,145,584 |  |  |
Exercise of options and warrants | $ 54 | 72,539 |  | 72,593
Exercise of options and warrants, shares | 54,235 |  |  |
Stock-based compensation |  | 2,964,767 |  | 2,964,767
Net loss |  |  | (31,809,838) | (31,809,838)
Balance at Dec. 31, 2016 | $ 23,249 | 154,254,193 | (118,976,311) | 35,301,131
Balance, shares at Dec. 31, 2016 | 23,250,023 |  |  |
Issuance of common stock, net of issuance costs | $ 11,038 | 113,536,146 |  | 113,547,184
Issuance of common stock, net of issuance costs, shares | 11,038,647 |  |  |
Exercise of options | $ 71 | 373,305 |  | 373,376
Exercise of options, shares | 71,129 |  |  |
Stock-based compensation |  | 3,760,802 |  | 3,760,802
Net loss |  |  | (33,281,068) | (33,281,068)
Balance at Dec. 31, 2017 | $ 34,358 | 271,944,173 | (152,277,106) | $ 119,701,425
Balance, shares at Dec. 31, 2017 | 34,359,799 |  |  |
Cumulative effect of adoption of ASU for stock-based compensation forfeitures | ASU 2016-09 |  | $ 19,727 | $ (19,727) |

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