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Statements of Operations and Comprehensive Loss - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Statements of Operations and Comprehensive (Loss) Income      
Revenue   $ 18,500 $ 20,070,750
Costs and expenses:      
Research and development expense $ 24,100,092 23,281,820 25,050,179
General and administrative expense 9,832,188 8,650,165 7,805,396
Total costs and expenses 33,932,280 31,931,985 32,855,575
Loss from operations (33,932,280) (31,913,485) (12,784,825)
Other income 651,212 103,647 15,327
Net loss and comprehensive loss $ (33,281,068) $ (31,809,838) $ (12,769,498)
Basic and diluted net loss per common share (in dollars per share) $ (1.13) $ (1.50) $ (0.67)
Basic and diluted weighted average number of common shares (in shares) 29,395,756 21,256,312 19,010,587