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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($)	Dec. 31, 2017	Dec. 31, 2016
Deferred tax assets:
Net operating loss carryforward	$ 30,813,509	$ 34,451,814
Capitalized start-up costs	1,695,688	2,708,479
Patent amortization	135,358	216,203
Research and orphan drug credits	21,293,509	14,988,522
Deferred rent	71,938	123,744
Deferred compensation	2,274,885	2,107,964
Other	69,906	70,511
Total gross deferred tax assets	56,354,793	54,667,237
Valuation allowance	$ (56,354,793)	$ (54,667,237)

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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