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Research and License Agreements - Additional Information (Detail)
1 Months Ended 12 Months Ended 27 Months Ended
Oct. 31, 2011
USD ($)
item
Feb. 29, 2004
Aug. 31, 2015
USD ($)
Jun. 30, 2015
USD ($)
May 31, 2014
USD ($)
Oct. 31, 2011
USD ($)
item
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2013
Feb. 29, 2016
USD ($)
Dec. 31, 2015
USD ($)
License Agreement                      
Research and License Agreements                      
Non-cash consideration received             $ 0        
Consideration paid             0        
License Agreement | Pfizer                      
Research and License Agreements                      
Milestone revenue     $ 20,000,000       0 $ 0      
Transaction price           $ 22,500,000          
Number of milestones included in transaction price | item           0          
License Agreement | Pfizer | Up-Front Payment Arrangement                      
Research and License Agreements                      
Upfront payment received $ 22,500,000                    
Recognition period of up-front payment                 1 year 6 months    
Research Services Agreement | University Of Basel                      
Research and License Agreements                      
Royalty payment due against license fees received (as a percent)   10.00%                  
Milestone license fee liability                   $ 2,000,000 $ 2,000,000
Milestone payment obligation             $ 0 $ 0      
Achievement Of Specified Development Milestone | License Agreement | Pfizer | Maximum                      
Research and License Agreements                      
Potential milestone payments $ 115,000,000                    
Number of indications | item 2                    
Achievement Of Specified Regulatory Milestone | License Agreement | Pfizer | Maximum                      
Research and License Agreements                      
Potential milestone payments $ 70,000,000                    
Number of indications | item 2                    
Achievement Of Specified Levels Of Annual Net Sales Of Licensed Products | License Agreement | Pfizer | Maximum                      
Research and License Agreements                      
Potential milestone payments $ 135,000,000                    
Achievement Of Dosing First Patient In Clinical Trial | License Agreement | Pfizer                      
Research and License Agreements                      
Milestone revenue       $ 20,000,000 $ 15,000,000