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Research and License Agreements - Additional Information (Detail)
1 Months Ended 3 Months Ended 6 Months Ended
Jun. 30, 2015
USD ($)
May 31, 2014
USD ($)
Oct. 31, 2011
USD ($)
item
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2018
USD ($)
item
Jun. 30, 2017
USD ($)
Research and License Agreements              
Revenue $ 20,000,000 $ 15,000,000  
Number of milestones included in transaction price | item           0  
License Agreement | Pfizer              
Research and License Agreements              
Up-front payment received     $ 22,500,000        
Revenue           $ 0 0
Transaction price           22,500,000  
Research Services Agreement | University Of Basel              
Research and License Agreements              
Milestone payment obligation       $ 0 $ 0 $ 0 $ 0
Royalty payment due against license fees received (as a percent)           10.00%  
Achievement Of Specified Development Milestone | License Agreement | Pfizer              
Research and License Agreements              
Non-refundable milestone payment received $ 20,000,000 $ 15,000,000          
Achievement Of Specified Development Milestone | License Agreement | Pfizer | Maximum              
Research and License Agreements              
Potential milestone payments     $ 115,000,000        
Number of indications | item     2        
Achievement Of Specified Regulatory Milestone | License Agreement | Pfizer | Maximum              
Research and License Agreements              
Potential milestone payments     $ 70,000,000        
Number of indications | item     2        
Achievement Of Specified Levels Of Annual Net Sales Of Licensed Products | License Agreement | Pfizer | Maximum              
Research and License Agreements              
Potential milestone payments     $ 135,000,000