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Income Taxes - NOLs and carryforwards (Detail) - USD ($) | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Unrecognized tax benefits | $ 0 | $ 0
Research tax credit carryforward |  |
Tax credits available to carry forward | 8,500,000 |
Orphan drug credit carryforward |  |
Tax credits available to carry forward | 19,600,000 |
U.S. Federal And State |  |
Net operating losses | $ 151,500,000 |

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