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Income Taxes - Reconciliation Between Statutory Federal Income Tax Rate and Effective Income Tax Rate (Detail) |  |  | 12 Months Ended
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Jan. 01, 2018 | Dec. 22, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Reconciliations between the statutory federal income tax rate and the effective income tax rate |  |  |  |  |
U.S. Federal statutory tax rate | 21.00% | 35.00% | 21.00% | 34.00% | 34.00%
State taxes |  |  | 5.70% | 4.40% | 4.60%
Research credit |  |  | 0.80% | 1.30% | 1.00%
Orphan drug credit |  |  | 10.40% | 11.50% | 9.00%
Other |  |  | 0.60% | 0.30% |
Stock-based compensation |  |  | (0.10%) | (0.70%) | (0.70%)
Change in valuation allowance |  |  | (38.40%) | (5.10%) | (47.90%)
Effective change due to corporate tax rate reduction |  |  |  | (45.70%) |

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