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Statements of Stockholders' Equity - USD ($) | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Total
--- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 19,049 | $ 127,619,078 | $ (87,166,473) | $ 40,471,654
Balance, shares at Dec. 31, 2015 | 19,050,204 |  |  |
Issuance of common stock, net of issuance costs | $ 4,146 | 23,597,809 |  | 23,601,955
Issuance of common stock, net of issuance costs, shares | 4,145,584 |  |  |
Exercise of options and warrants | $ 54 | 72,539 |  | 72,593
Exercise of options and warrants, shares | 54,235 |  |  |
Stock-based compensation |  | 2,964,767 |  | 2,964,767
Net loss |  |  | (31,809,838) | (31,809,838)
Balance at Dec. 31, 2016 | $ 23,249 | 154,254,193 | (118,976,311) | 35,301,131
Balance, shares at Dec. 31, 2016 | 23,250,023 |  |  |
Issuance of common stock, net of issuance costs | $ 11,038 | 113,536,146 |  | 113,547,184
Issuance of common stock, net of issuance costs, shares | 11,038,647 |  |  |
Exercise of options | $ 71 | 373,305 |  | 373,376
Exercise of options, shares | 71,129 |  |  |
Stock-based compensation |  | 3,760,802 |  | 3,760,802
Net loss |  |  | (33,281,068) | (33,281,068)
Balance at Dec. 31, 2017 | $ 34,358 | 271,944,173 | (152,277,106) | 119,701,425
Balance, shares at Dec. 31, 2017 | 34,359,799 |  |  |
Cumulative adjustment upon implementation of ASU No. 2016-09 for stock-based compensation forfeitures | ASU 2016-09 |  | 19,727 | (19,727) |
Issuance of common stock, net of issuance costs | $ 8,050 | 128,417,030 |  | 128,425,080
Issuance of common stock, net of issuance costs, shares | 8,050,000 |  |  |
Exercise of options and warrants | $ 751 | 1,023,774 |  | 1,024,525
Exercise of options and warrants, shares | 750,952 |  |  |
Stock-based compensation |  | 4,587,098 |  | 4,587,098
Net loss |  |  | (48,273,633) | (48,273,633)
Balance at Dec. 31, 2018 | $ 43,159 | $ 405,972,075 | $ (200,550,739) | $ 205,464,495
Balance, shares at Dec. 31, 2018 | 43,160,751 |  |  |

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