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Stockholders' Equity - Stock-Based Compensation Expense (Detail) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Stock-based compensation expense |  |  |
Total stock-based compensation expense | $ 4,587,098 | $ 3,760,802 | $ 2,964,767
Research and Development |  |  |
Stock-based compensation expense |  |  |
Total stock-based compensation expense | 1,709,390 | 1,280,909 | 1,033,005
General and Administrative Expense. |  |  |
Stock-based compensation expense |  |  |
Total stock-based compensation expense | $ 2,877,708 | $ 2,479,893 | $ 1,931,762

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