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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($) | Dec. 31, 2018 | Dec. 31, 2017
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Deferred tax assets: |  |
Net operating loss carryforward | $ 41,687,577 | $ 30,813,509
Capitalized start-up costs | 1,501,895 | 1,695,688
Patent amortization | 119,888 | 135,358
Research and orphan drug credits | 28,123,082 | 21,293,509
Deferred rent | 51,400 | 71,938
Deferred compensation | 3,293,221 | 2,274,885
Other | 95,564 | 69,906
Total gross deferred tax assets | 74,872,627 | 56,354,793
Valuation allowance | (74,872,627) | (56,354,793)
Deferred tax assets |  |
Deferred tax liabilities: |  |
Total deferred tax liabilities |  |
Net deferred tax assets |  |

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