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Statements of Operations and Comprehensive Loss - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Statements of Operations and Comprehensive Loss      
Revenue     $ 18,500
Costs and expenses:      
Research and development expense $ 40,091,773 $ 24,100,092 23,281,820
General and administrative expense 11,413,050 9,832,188 8,650,165
Total costs and expenses 51,504,823 33,932,280 31,931,985
Loss from operations (51,504,823) (33,932,280) (31,913,485)
Interest income 3,231,190 651,212 103,647
Net loss and comprehensive loss $ (48,273,633) $ (33,281,068) $ (31,809,838)
Basic and diluted net loss per common share (in dollars per share) $ (1.18) $ (1.13) $ (1.50)
Basic and diluted weighted average number of common shares (in shares) 41,044,621 29,395,756 21,256,312