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Statements of Stockholders' Equity - USD ($)
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Total
Balance at Dec. 31, 2015 $ 19,049 $ 127,619,078 $ (87,166,473) $ 40,471,654
Balance, shares at Dec. 31, 2015 19,050,204      
Issuance of common stock, net of issuance costs $ 4,146 23,597,809   23,601,955
Issuance of common stock, net of issuance costs, shares 4,145,584      
Exercise of options and warrants $ 54 72,539   72,593
Exercise of options and warrants, shares 54,235      
Stock-based compensation   2,964,767   2,964,767
Net loss     (31,809,838) (31,809,838)
Balance at Dec. 31, 2016 $ 23,249 154,254,193 (118,976,311) 35,301,131
Balance, shares at Dec. 31, 2016 23,250,023      
Issuance of common stock, net of issuance costs $ 11,038 113,536,146   113,547,184
Issuance of common stock, net of issuance costs, shares 11,038,647      
Exercise of options $ 71 373,305   373,376
Exercise of options, shares 71,129      
Stock-based compensation   3,760,802   3,760,802
Net loss     (33,281,068) (33,281,068)
Balance at Dec. 31, 2017 $ 34,358 271,944,173 (152,277,106) 119,701,425
Balance, shares at Dec. 31, 2017 34,359,799      
Cumulative adjustment upon implementation of ASU No. 2016-09 for stock-based compensation forfeitures | ASU 2016-09   19,727 (19,727)  
Issuance of common stock, net of issuance costs $ 8,050 128,417,030   128,425,080
Issuance of common stock, net of issuance costs, shares 8,050,000      
Exercise of options and warrants $ 751 1,023,774   1,024,525
Exercise of options and warrants, shares 750,952      
Stock-based compensation   4,587,098   4,587,098
Net loss     (48,273,633) (48,273,633)
Balance at Dec. 31, 2018 $ 43,159 $ 405,972,075 $ (200,550,739) $ 205,464,495
Balance, shares at Dec. 31, 2018 43,160,751