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Stockholders Equity (Tables)

12 Months Ended

Dec. 31, 2018

Stock-Based Compensation Expense

		2018			2017			2016
Research and development expense		$	1,709,390		$	1,280,909		$	1,033,005
General and administrative expense			2,877,708			2,479,893			1,931,762
Total stock-based compensation expense		$	4,587,098		$	3,760,802		$	2,964,767

2003 Stock Incentive Plan

Company's Stock Option Activity

							Weighted-Average
							Remaining		Aggregate
		Outstanding		Weighted-Average			Contractual Term		Intrinsic Value
		Options		Exercise Price			(Years)		(In thousands)
Outstanding as of December 31, 2017		713,211		$	1.25		2.2
Options exercised		(46,131)			1.29
Options forfeited		—			—
Outstanding, Vested and Exercisable as of December 31, 2018		667,080			1.24		1.2		$	5,488

2013 Equity Incentive Plan

Company's Stock Option Activity

							WEIGHTED-
				WEIGHTED-			AVERAGE		AGGREGATE
				AVERAGE			REMAINING		INTRINSIC
		OUTSTANDING		EXERCISE			CONTRACTUAL		VALUE (IN
		OPTIONS		PRICE			TERM(YEARS)		THOUSANDS)
Outstanding as of December 31, 2017		2,664,163		$	7.34		7.4
Options granted		845,479			19.22
Options exercised		(144,182)			6.68
Options forfeited		(100,206)			13.89
Outstanding as of December 31, 2018		3,265,254			8.39		7.1		$	7,489
Vested or expected to vest as of December 31, 2018		3,265,254			8.39		7.1		$	7,489
Exercisable as of December 31, 2018		2,020,307			7.66		6.1		$	4,539

Weighted-Average Fair Value of Options Granted

		2018		2017		2016
Expected term		6.25 years		6.25 years		6.25 years
Expected volatility		73.75%		75.20%		68.98%
Risk-free interest rate		2.55%		2.08%		1.70%
Expected dividend yield		0%		0%		0%

Summary of RSU Activity

The following is a summary of RSU activity for the 2013 Plan for the year ended December 31, 2018:

					Weighted-Average
			Number of Shares		Grant Date
		Underlying RSUs				Fair Value
Unvested at December 31, 2017			9,667		$	4.61
Granted			—			—
Forfeited			—			—
Vested			4,834			4.61
Unvested at December 31, 2018			4,833			4.61

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