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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Deferred tax assets:
Net operating loss carryforward	$ 41,687,577	$ 30,813,509
Capitalized start-up costs	1,501,895	1,695,688
Patent amortization	119,888	135,358
Research and orphan drug credits	28,123,082	21,293,509
Deferred rent	51,400	71,938
Deferred compensation	3,293,221	2,274,885
Other	95,564	69,906
Total gross deferred tax assets	74,872,627	56,354,793
Valuation allowance	(74,872,627)	(56,354,793)
Deferred tax assets
Deferred tax liabilities:
Total deferred tax liabilities
Net deferred tax assets

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