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Income Taxes - NOLs and carryforwards (Detail) - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Unrecognized tax benefits	$ 0	$ 0
Research tax credit carryforward
Tax credits available to carry forward	8,500,000
Orphan drug credit carryforward
Tax credits available to carry forward	19,600,000
U.S. Federal And State
Net operating losses	$ 151,500,000

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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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