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Unaudited Statements of Stockholders' Equity - USD ($) | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Total
--- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ 34,358 | $ 271,944,173 | $ (152,277,106) | $ 119,701,425
Balance, shares at Dec. 31, 2017 | 34,359,799 |  |  |
Net loss |  |  |  | (11,278,763)
Balance at Mar. 31, 2018 | $ 42,489 | 401,786,661 | (163,789,950) | 238,039,200
Balance, shares at Mar. 31, 2018 | 42,490,110 |  |  |
Balance at Dec. 31, 2017 | $ 34,358 | 271,944,173 | (152,277,106) | 119,701,425
Balance, shares at Dec. 31, 2017 | 34,359,799 |  |  |
Issuance of common stock, net of issuance costs | $ 8,050 | 128,417,030 |  | 128,425,080
Issuance of common stock, net of issuance costs, shares | 8,050,000 |  |  |
Exercise of options and warrants | $ 646 | 393,140 |  | 393,786
Exercise of options and warrants, shares | 645,625 |  |  |
Stock-based compensation |  | 2,266,219 |  | 2,266,219
Net loss |  |  | (22,791,607) | (22,791,607)
Balance at Jun. 30, 2018 | $ 43,054 | 403,020,562 | (175,068,713) | 227,994,903
Balance, shares at Jun. 30, 2018 | 43,055,424 |  |  |
Balance at Mar. 31, 2018 | $ 42,489 | 401,786,661 | (163,789,950) | 238,039,200
Balance, shares at Mar. 31, 2018 | 42,490,110 |  |  |
Issuance of common stock, net of issuance costs |  | (10,920) |  | (10,920)
Exercise of options and warrants | $ 565 | 94,432 |  | 94,997
Exercise of options and warrants, shares | 565,314 |  |  |
Stock-based compensation |  | 1,150,389 |  | 1,150,389
Net loss |  |  | (11,278,763) | (11,278,763)
Balance at Jun. 30, 2018 | $ 43,054 | 403,020,562 | (175,068,713) | 227,994,903
Balance, shares at Jun. 30, 2018 | 43,055,424 |  |  |
Balance at Dec. 31, 2018 | $ 43,159 | 405,972,075 | (200,550,739) | 205,464,495
Balance, shares at Dec. 31, 2018 | 43,160,751 |  |  |
Net loss |  |  |  | (15,829,815)
Balance at Mar. 31, 2019 | $ 43,179 | 407,385,052 | (214,634,636) | 192,793,595
Balance, shares at Mar. 31, 2019 | 43,180,169 |  |  |
Balance at Dec. 31, 2018 | $ 43,159 | 405,972,075 | (200,550,739) | 205,464,495
Balance, shares at Dec. 31, 2018 | 43,160,751 |  |  |
Exercise of options | $ 33 | 106,288 |  | 106,321
Exercise of options, shares | 32,439 |  |  |
Stock-based compensation |  | 2,901,839 |  | 2,901,839
Net loss |  |  | (29,913,712) | (29,913,712)
Balance at Jun. 30, 2019 | $ 43,192 | 408,980,202 | (230,464,451) | 178,558,943
Balance, shares at Jun. 30, 2019 | 43,193,190 |  |  |
Balance at Mar. 31, 2019 | $ 43,179 | 407,385,052 | (214,634,636) | 192,793,595
Balance, shares at Mar. 31, 2019 | 43,180,169 |  |  |
Exercise of options | $ 13 | 75,755 |  | 75,768
Exercise of options, shares | 13,021 |  |  |
Stock-based compensation |  | 1,519,395 |  | 1,519,395
Net loss |  |  | (15,829,815) | (15,829,815)
Balance at Jun. 30, 2019 | $ 43,192 | $ 408,980,202 | $ (230,464,451) | $ 178,558,943
Balance, shares at Jun. 30, 2019 | 43,193,190 |  |  |

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