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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($) | Dec. 31, 2021 | Dec. 31, 2020
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Deferred income tax assets: |  |
Net operating loss carryforward | $ 79,788,146 | $ 63,830,866
Capitalized start-up costs | 920,516 | 1,114,309
Patent amortization | 73,480 | 88,949
Research and orphan drug credits | 47,976,370 | 42,008,797
Stock-based compensation | 7,102,947 | 6,778,569
Operating lease liabilities | 528,340 | 775,598
Accrued bonus | 592,260 | 919,410
Other | 209,580 | 283,751
Gross deferred income tax assets | 137,191,639 | 115,800,249
Valuation allowance | (136,613,829) | (115,016,323)
Net deferred income tax assets | 577,810 | 783,926
Deferred tax liabilities: |  |
Operating lease right-of-use assets | (433,727) | (639,843)
Property and equipment | (144,083) | (144,083)
Gross deferred income tax liabilities | (577,810) | (783,926)
Net deferred income tax asset/(liability) |  |

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