XML 19 R4.htm IDEA: XBRL DOCUMENT v3.22.0.1
Statements of Operations and Comprehensive Loss - USD ($)
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Statements of Operations and Comprehensive Loss      
Revenue from collaboration and license agreements $ 1,159,767 $ 10,162,935  
Costs and expenses:      
Research and development expense 47,491,567 44,929,198 $ 47,029,264
General and administrative expense 17,115,405 16,743,127 14,360,038
Total costs and expenses 64,606,972 61,672,325 61,389,302
Loss from operations (63,447,205) (51,509,390) (61,389,302)
Interest income 19,768 482,487 3,497,391
Net loss and comprehensive loss $ (63,427,437) $ (51,026,903) $ (57,891,911)
Basic net loss per common share (in dollars per share) $ (1.23) $ (1.12) $ (1.34)
Diluted net loss per common share (in dollars per share) $ (1.23) $ (1.12) $ (1.34)
Basic weighted-average number of common shares outstanding (in shares) 51,453,204 45,721,139 43,254,782
Diluted weighted-average number of common shares outstanding (in shares) 51,453,204 45,721,139 43,254,782