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Income Taxes - Schedule of Gross Deferred Tax Asset and Related Valuation Allowance (Detail) - USD ($)	Dec. 31, 2021	Dec. 31, 2020
Deferred income tax assets:
Net operating loss carryforward	$ 79,788,146	$ 63,830,866
Capitalized start-up costs	920,516	1,114,309
Patent amortization	73,480	88,949
Research and orphan drug credits	47,976,370	42,008,797
Stock-based compensation	7,102,947	6,778,569
Operating lease liabilities	528,340	775,598
Accrued bonus	592,260	919,410
Other	209,580	283,751
Gross deferred income tax assets	137,191,639	115,800,249
Valuation allowance	(136,613,829)	(115,016,323)
Net deferred income tax assets	577,810	783,926
Deferred tax liabilities:
Operating lease right-of-use assets	(433,727)	(639,843)
Property and equipment	(144,083)	(144,083)
Gross deferred income tax liabilities	(577,810)	(783,926)
Net deferred income tax asset/(liability)

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