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Stockholders' Equity - Inducement Plan (Details) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Jan. 09, 2014 installment shares | May 31, 2022 shares | Jan. 31, 2022 USD ($) shares | Aug. 31, 2021 shares | Jan. 31, 2020 installment shares | Mar. 31, 2021 shares | Jun. 30, 2022 USD ($) shares | Jun. 30, 2021 USD ($) shares | Dec. 31, 2021 shares
Inducement Plan |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Period from date of termination that any vested options shall expire |  |  |  |  | 90 days |  |  |  |
Expiration period |  |  |  |  | 10 years |  |  |  |
Unrecognized compensation expense related to unvested options | $ |  |  |  |  |  |  | $ 1,645,467 |  |
Period for unrecognized compensation expense related to unvested options yet has not been recognized |  |  |  |  |  |  | 3 years 2 months 12 days |  |
Increase in number of shares of common stock |  |  | 3,000,000 | 2,000,000 |  |  |  |  |
Shares available for future grants |  |  |  |  |  |  | 848,424 |  |
Stock options granted |  |  |  |  |  |  | 335,000 |  |
Fair value of shares vested | $ |  |  |  |  |  |  | $ 20,002 | $ 17,591 |
Inducement Plan | Upon first anniversary of start date |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Vesting percentage |  |  |  |  | 25.00% |  |  |  |
Inducement Plan | Each month after the first anniversary |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Number of monthly installments | installment |  |  |  |  | 36 |  |  |  |
2013 Equity Incentive Plan |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Period from date of termination that any vested options shall expire | 90 days |  |  |  |  |  |  |  |
Expiration period | 10 years |  |  |  |  |  |  |  |
Common stock authorized | 1,000,000 |  |  |  |  |  | 9,506,767 |  |
Period for unrecognized compensation expense related to unvested options yet has not been recognized |  |  |  |  |  |  | 2 years 1 month 6 days |  |
Increase in number of shares of common stock |  | 2,619,622 |  |  |  |  |  |  |
Shares available for future grants |  |  |  |  |  |  | 1,469,324 |  |
Stock options granted |  |  |  |  |  |  | 1,980,800 |  |
Fair value of shares vested | $ |  |  |  |  |  |  | $ 2,060,622 | $ 3,745,954 |
Options exercised |  |  |  |  |  |  | 0 | 0 |
2013 Equity Incentive Plan | Stock options vesting based on performance |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Vesting percentage |  |  | 50.00% |  |  |  |  |  |
Maximum fair value of option excluded from the unrecognized compensation expense | $ |  |  |  |  |  |  | $ 825,353 |  |
2013 Equity Incentive Plan | Stock options vesting based on performance | Employees |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Stock options granted |  |  | 202,600 |  |  |  |  |  |
Maximum fair value of option excluded from the unrecognized compensation expense | $ |  |  | $ 162,080 |  |  |  |  |  |
2013 Equity Incentive Plan | Stock options vesting based on performance | Newly hired employees |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Stock options granted |  |  |  |  |  |  | 584,200 |  | 584,200
2013 Equity Incentive Plan | Upon first anniversary of start date |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Vesting percentage | 25.00% |  |  |  |  |  |  |  |
Number of monthly installments | installment | 36 |  |  |  |  |  |  |  |
2013 Equity Incentive Plan | Vesting upon FDA Approval | Stock options vesting based on performance |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Vesting percentage |  |  | 50.00% |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Options exercised |  |  |  |  |  | 3,785 |  |  |
Common Stock | Inducement Plan |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |  |  |
Common stock authorized |  |  |  |  | 500,000 |  |  |  |

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