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Stockholders' Equity - Stock-Based Compensation Expense (Details) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021
Stock-based compensation expense |  |  |  |
Total stock-based compensation expense | $ 913,979 | $ 1,590,859 | $ 2,958,379 | $ 4,767,205
Research and Development |  |  |  |
Stock-based compensation expense |  |  |  |
Total stock-based compensation expense | 242,627 | 586,001 | 831,502 | 1,884,294
General and Administrative Expense |  |  |  |
Stock-based compensation expense |  |  |  |
Total stock-based compensation expense | $ 671,352 | $ 1,004,858 | $ 2,126,877 | $ 2,882,911

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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